Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

被引：43
作者：
Benhamou, P. Y. [1 ]
Milliat-Guittard, L. [2 ,10 ]
Wojtusciszyn, A. [3 ]
Kessler, L. [4 ,11 ]
Toso, C. [5 ]
Baertschiger, R. [5 ]
Debaty, I.
Badet, L. [9 ]
Penfornis, A. [6 ]
Thivolet, C. [7 ,10 ,12 ]
Renard, E. [3 ]
Bayle, F. [8 ]
Morel, P. [5 ]
Morelon, E. [9 ,10 ]
Colin, C. [2 ,10 ]
Berney, T. [5 ]
机构：
[1] CHU Grenoble, Dept Endocrinol, Clin Endocrinol, F-38043 Grenoble, France
[2] Univ Lyon, EA Sante Individu Soc 4129, Lyon, France
[3] Ctr Hosp Montpellier, Serv Endocrinol, Montpellier, France
[4] Univ Strasbourg, Fac Med, Strasbourg, France
[5] Univ Hosp Geneva, Dept Surg, Geneva, Switzerland
[6] Hop Jean Minjoz, Serv Endocrinol Metab & Diabet Nutr, F-25030 Besancon, France
[7] Univ Lyon, Fac Laennec, INSERM, U449, Lyon, France
[8] CHU Grenoble, Serv Nephrol, F-38043 Grenoble, France
[9] Hosp Civiles Lyon, Serv Nephrol Med Transplantat & Immunol, Clin Pavillon P, Lyon, France
[10] Univ Lyon 1, F-69365 Lyon, France
[11] Hop Univ Strasbourg, Serv Endocrinol Diabet & Malad Metabol, Strasbourg, France
[12] Hosp Civils Lyon, Serv Endocrinol Diabete Nutr Pavillon X, Lyon, France
来源：
DIABETIC MEDICINE | 2009年 / 26卷 / 06期
关键词：
health-related quality of life; pancreatic islet transplantation; Type 1 diabetes mellitus;
D O I：
10.1111/j.1464-5491.2009.02731.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
引用
收藏
页码：617 / 621
页数：5
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