Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection

被引：17
作者：
Al-Kindi, Sadeer G. [1 ]
Kim, Chang H. [1 ]
Morris, Stephen R. [1 ]
Freeman, Michael L. [2 ]
Funderburg, Nicholas T. [3 ]
Rodriguez, Benigno [2 ]
McComsey, Grace A. [4 ]
Dalton, Jarrod E. [5 ]
Simon, Daniel I. [1 ]
Lederman, Michael M. [2 ]
Longenecker, Chris T. [1 ]
Zidar, David A. [1 ]
机构：
[1] Univ Hosp Cleveland, Med Ctr, Harrington Heart & Vasc Inst, 11100 Euclid Ave,Mailstop LKS 5038, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Med, Div Infect Dis & HIV Med, Ctr AIDS Res,Univ Hosp Cleveland,Med Ctr, Cleveland, OH 44106 USA
[3] Ohio State Univ, Sch Hlth & Rehabil Sci, Div Med Lab Sci, Columbus, OH 43210 USA
[4] Case Western Reserve Univ, Sch Med, Cleveland, OH USA
[5] Cleveland Clin, Sect Hlth Outcomes Res & Clin Epidemiol, Lerner Res Inst, Cleveland, OH 44106 USA
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2017年 / 74卷 / 03期
基金：
美国国家卫生研究院;
关键词：
cardiovascular disease; coronary; peripheral; heart failure; RDW; ACUTE HEART-FAILURE; PROGNOSTIC MARKER; ARTERY-DISEASE; MYOCARDIAL-INFARCTION; UNITED-STATES; HOSPITALIZATION; PATTERNS; OUTCOMES; HEALTH; COHORT;
D O I：
10.1097/QAI.0000000000001231
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (> 14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.
引用
收藏
页码：298 / 302
页数：5
相关论文
共 36 条
  • [11] Patterns of Cardiovascular Mortality for HIV-Infected Adults in the United States: 1999 to 2013
    Feinstein, Matthew J.
    Bahiru, Ehete
    Achenbach, Chad
    Longenecker, Christopher T.
    Hsue, Priscilla
    So-Armah, Kaku
    Freiberg, Matthew S.
    Lloyd-Jones, Donald M.
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2016, 117 (02) : 214 - 220
  • [12] Red cell distribution width as a novel prognostic marker in heart failure - Data from the CHARM program and the Duke Databank
    Felker, G. Michael
    Allen, Larry A.
    Pocock, Stuart J.
    Shaw, Linda K.
    McMurray, John J. V.
    Pfeffer, Marc A.
    Swedberg, Karl
    Wang, Duolao
    Yusuf, Salim
    Michelson, Eric L.
    Granger, Christopher B.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (01) : 40 - 47
  • [13] Cardiovascular disease risk factors in HIV patients -: association with antiretroviral therapy.: Results from the DAD study
    Friis-Moller, N
    Weber, R
    Reiss, P
    Thiébaut, R
    Kirk, O
    Monforte, AD
    Pradier, C
    Morfeldt, L
    Mateu, S
    Law, M
    El-Sadr, W
    De Wit, S
    Sabin, CA
    Phillips, AN
    Lundgren, JD
    [J]. AIDS, 2003, 17 (08) : 1179 - 1193
  • [14] Gallego ML, 2012, OPEN J INTERN MED, V2, P7, DOI DOI 10.HTTPS://D0I.0RG/10.4236/0JIM.2012.21002
  • [15] The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up
    Gul, Mehmet
    Uyarel, Huseyin
    Ergelen, Mehmet
    Karacimen, Denizhan
    Ugur, Murat
    Turer, Ayca
    Bozbay, Mehmet
    Ayhan, Erkan
    Akgul, Ozgur
    Uslu, Nevzat
    [J]. CORONARY ARTERY DISEASE, 2012, 23 (05) : 330 - 336
  • [16] Elevated levels of RDW is associated with non-valvular atrial fibrillation
    Gungor, Baris
    Ozcan, Kazim Serhan
    Erdinler, Izzet
    Ekmekci, Ahmet
    Alper, Ahmet Taha
    Osmonov, Damirbek
    Calik, Nazmi
    Akyuz, Sukru
    Toprak, Ercan
    Yilmaz, Hale
    Yildirim, Aydin
    Bolca, Osman
    [J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2014, 37 (04) : 404 - 410
  • [17] Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease
    Isik, Turgay
    Uyarel, Huseyin
    Tanboga, Ibrahim Halil
    Kurt, Mustafa
    Ekinci, Mehmet
    Kaya, Ahmet
    Ayhan, Erkan
    Ergelen, Mehmet
    Bayram, Ednan
    Gibson, Charles Michael
    [J]. CORONARY ARTERY DISEASE, 2012, 23 (01) : 51 - 56
  • [18] Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure
    Jackson, Colette E.
    Dalzell, Jonathan R.
    Bezlyak, Vladimir
    Tsorlalis, Ioannis K.
    Myles, Rachel C.
    Spooner, Richard
    Ford, Ian
    Petrie, Mark C.
    Cobbe, Stuart M.
    McMurray, John J. V.
    [J]. EUROPEAN JOURNAL OF HEART FAILURE, 2009, 11 (12) : 1152 - 1154
  • [19] Patient characteristics associated with venous thromboembolic events: a cohort study using pooled electronic health record data
    Kaelber, David C.
    Foster, Wendy
    Gilder, Jason
    Love, Thomas E.
    Jain, Anil K.
    [J]. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2012, 19 (06) : 965 - 972
  • [20] Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals
    Longenecker, C. T.
    Funderburg, N. T.
    Jiang, Y.
    Debanne, S.
    Storer, N.
    labbato, D. E.
    Lederman, M. M.
    McComsey, G. A.
    [J]. HIV MEDICINE, 2013, 14 (06) : 385 - 390
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