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- [40] In smoldering/indolent multiple myeloma (SMM/IMM) patients, interleukin-1 receptor antagonist (IL-1Ra) can decrease the C-reactive protein (CRP), plasma cell labeling index (PC-LI), and percent bone marrow plasma cells:: Relevance of the IL-1β/IL-6 axis to the progression of SMM/IMM to active MM. BLOOD, 2003, 102 (11) : 685A - 685A