Steroidal saponins from Nolina recurvata stems and their inhibitory activity on cyclic AMP phosphodiesterase

被引：50

作者：

Mimaki, Y ^{[1
]}

Takaashi, Y ^{[1
]}

Kuroda, M ^{[1
]}

Sashida, Y ^{[1
]}

Nikaido, T ^{[1
]}

机构：

[1] TOHO UNIV,SCH PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

PHYTOCHEMISTRY | 1996年 / 42卷 / 06期

关键词：

Nolina recurvata; Agavaceae; steroidal saponins; cyclic AMP phosphodiesterase inhibition;

D O I：

10.1016/0031-9422(96)00107-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven steroidal saponins were isolated from the stems of Nolina recurvata, five of which appeared to be new compounds and were assigned as spirosta-5,25(27)-diene-1 beta,3 beta-diol (neoruscogenin) 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-alpha-L-arabinopyranoside}, (25S)-spirost-5-ene-1 beta,3 beta-diol [(25S)-ruscogenin] 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-alpha-l-arabinopyranoside}, neoruscogenin 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1 -->3)]-beta-D-fucopyranoside}, 26-O-beta-D-glucopyranosyl-22-O-methylfurosta-5,25(27)-diene-1 beta,3 beta,22 xi,26-tetrol 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-xylopyranosyl-(1-->3)]-alpha-L-arabinopyranoside} and 26-O-beta-D-glucopyranosylfurosta-5,20(22),25(27)-triene-1 beta,3 beta,26-triol 1-O-{O-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside}. The isolated saponins were evaluated for their inhibitory activity on cyclic AMP phosphodiesterase to identify new compounds with medicinal potential.

引用

页码：1609 / 1615

页数：7

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