The dynamic lifecycle of mRNA in the nucleus

被引：10
作者：
Ben-Yishay, Rakefet [1 ,2 ]
Shav-Tal, Yaron [1 ,2 ]
机构：
[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, Ramat Gan, Israel
[2] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, Ramat Gan, Israel
来源：
CURRENT OPINION IN CELL BIOLOGY | 2019年 / 58卷
基金：
以色列科学基金会;
关键词：
IN-VIVO; GENE-EXPRESSION; SINGLE CELLS; REAL-TIME; TRANSCRIPTION; LOCALIZATION; ORGANIZATION; TRANSLATION; SPECKLES; REVEALS;
D O I：
10.1016/j.ceb.2019.02.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The mRNA molecule roams through the nucleus on its way out to the cytoplasm. mRNA encounters and is bound by many protein factors, from the moment it begins to emerge from RNA polymerase II and during its travel in the nucleoplasm, where it will come upon chromatin and nuclear bodies. Some of the protein factors that engage with the mRNA can process it, until finally reaching a mature state fit for export through the nuclear pore complex (NPC). Examining the lifecycle of mRNAs in living cells using mRNA tagging techniques opens a window into our understanding of the rules that drive the dynamics of gene expression from transcription to mRNA export.
引用
收藏
页码：69 / 75
页数：7
相关论文
共 72 条
[1]   RNA targeting with CRISPR-Cas13 [J].
Abudayyeh, Omar O. ;
Gootenberg, Jonathan S. ;
Essletzbichler, Patrick ;
Han, Shuo ;
Joung, Julia ;
Belanto, Joseph J. ;
Verdine, Vanessa ;
Cox, David B. T. ;
Kellner, Max J. ;
Regev, Aviv ;
Lander, Eric S. ;
Voytas, Daniel F. ;
Ting, Alice Y. ;
Zhang, Feng .
NATURE, 2017, 550 (7675) :280-+
[2]   Nup42 and IP6 coordinate Gle1 stimulation of Dbp5/DDX19B for mRNA export in yeast and human cells [J].
Adams, Rebecca L. ;
Mason, Aaron C. ;
Glass, Laura ;
Aditi ;
Wente, Susan R. .
TRAFFIC, 2017, 18 (12) :776-790
[3]   Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells [J].
Autour, Alexis ;
Jeng, Sunny C. Y. ;
Cawte, Adam D. ;
Abdolahzadeh, Amir ;
Galli, Angela ;
Panchapakesan, Shanker S. S. ;
Rueda, David ;
Ryckelynck, Michael ;
Unrau, Peter J. .
NATURE COMMUNICATIONS, 2018, 9
[4]   Visualizing nuclear RNAi activity in single living human cells [J].
Avivi, Shira ;
Mor, Amir ;
Dotan, Iris ;
Tzadok, Sivan ;
Kanter, Itamar ;
Kinor, Noa ;
Canaani, Dan ;
Shav-Tal, Yaron .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (42) :E8837-E8846
[5]   Control of Transcript Variability in Single Mammalian Cells [J].
Battich, Nico ;
Stoeger, Thomas ;
Pelkmans, Lucas .
CELL, 2015, 163 (07) :1596-1610
[6]   Dynamic Encounters of Genes one Transcripts with the Nuclear Pore [J].
Ben-Yishay, Rakefet ;
Ashkenazy, Asaf J. ;
Shav-Tal, Yaron .
TRENDS IN GENETICS, 2016, 32 (07) :419-431
[7]   Localization of ASH1 mRNA particles in living yeast [J].
Bertrand, E ;
Chartrand, P ;
Schaefer, M ;
Shenoy, SM ;
Singer, RH ;
Long, RM .
MOLECULAR CELL, 1998, 2 (04) :437-445
[8]   The transcriptional cycle of HIV-1 in real-time and live cells [J].
Boireau, Stephanie ;
Maiuri, Paolo ;
Basyuk, Eugenia ;
de la Mata, Manuel ;
Knezevich, Anna ;
Pradet-Balade, Berangere ;
Baecker, Volker ;
Kornblihtt, Alberto ;
Marcello, Alessandro ;
Bertrand, Edouard .
JOURNAL OF CELL BIOLOGY, 2007, 179 (02) :291-304
[9]   A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells [J].
Braselmann, Esther ;
Wierzba, Aleksandra J. ;
Polaski, Jacob T. ;
Chrominski, Mikolaj ;
Holmes, Zachariah E. ;
Hung, Sheng-Ting ;
Batan, Dilara ;
Wheeler, Joshua R. ;
Parker, Roy ;
Jimenez, Ralph ;
Gryko, Dorota ;
Batey, Robert T. ;
Palmer, Amy E. .
NATURE CHEMICAL BIOLOGY, 2018, 14 (10) :964-+
[10]   A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus [J].
Castanotto, Daniela ;
Zhang, Xiaowei ;
Alluin, Jessica ;
Zhang, Xizhe ;
Rueger, Jacqueline ;
Armstrong, Brian ;
Rossi, John ;
Riggs, Arthur ;
Stein, C. A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (25) :E5756-E5765
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