A new role for histone demethylases in the maintenance of plant genome integrity

被引：38

作者：

Antunez-Sanchez, Javier ^{[1
]}

Naish, Matthew ^{[1
,11
]}

Ramirez-Prado, Juan Sebastian ^{[2
,12
]}

Ohno, Sho ^{[1
,3
]}

Huang, Ying ^{[2
]}

Dawson, Alexander ^{[1
]}

Opassathian, Korawit ^{[1
]}

Manza-Mianza, Deborah ^{[2
]}

Ariel, Federico ^{[2
]}

Raynaud, Cecile ^{[2
]}

Wibowo, Anjar ^{[4
,13
]}

Daron, Josquin ^{[5
,14
]}

Ueda, Minako ^{[6
,7
,15
]}

Latrasse, David ^{[2
]}

Slotkin, R. Keith ^{[8
,9
]}

Weigel, Detlef ^{[4
]}

Benhamed, Moussa ^{[2
,10
]}

Gutierrez-Marcos, Jose ^{[1
]}

机构：

[1] Univ Warwick, Sch Life Sci, Coventry, W Midlands, England

[2] Univ Paris Saclay, Univ Evry, Inst Plant Sci Paris Saclay IPS2, INRAE, Orsay, France

[3] Kyoto Univ, Grad Sch Agr, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto, Japan

[4] Max Planck Inst Dev Biol, Dept Mol Biol, Tubingen, Germany

[5] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[6] Nagoya Univ, Inst Transformat Biomol, Nagoya, Aichi, Japan

[7] Nagoya Univ, Grad Sch Sci, Div Biol Sci, Nagoya, Aichi, Japan

[8] Donald Danforth Plant Sci Ctr, St Louis, MO USA

[9] Univ Missouri, Div Biol Sci, Columbia, MO USA

[10] Univ Paris, Inst Plant Sci Paris Saclay IPS2, F-75006 Paris, France

[11] Univ Cambridge, Dept Plant Sci, Cambridge, England

[12] Katholieke Univ Leuven, Ctr Microbial & Plant Genet, PSB VIB, Ctr Plant Syst Biol, Leuven, Belgium

[13] Airlangga Univ, Fac Sci & Technol, Kampus C, Mulyorejo, Indonesia

[14] Univ Montpellier, Lab MIVEGEC, CNRS, IRD, Montpellier, France

[15] Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi, Japan

来源：

ELIFE | 2020年 / 9卷

基金：

日本学术振兴会; 英国生物技术与生命科学研究理事会;

关键词：

DNA METHYLATION; TRANSPOSON METHYLATION; H3; METHYLATION; CHROMATIN; POLYCOMB; LYSINE-27; TRANSCRIPTION; REF6; LHP1; HETEROCHROMATIN;

D O I：

10.7554/eLife.58533

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.

引用

页码：1 / 32

页数：23

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