Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan

被引：16

作者：

Cui, Zining ^{[1
,3
,4
]}

Li, Xinghai ^{[2
]}

Nishida, Yoshihiro ^{[3
]}

机构：

[1] South China Agr Univ, Coll Nat Resource & Environm, Dept Plant Pathol, Guangdong Prov Key Lab Microbial Signals & Dis Co, Guangzhou 510642, Guangdong, Peoples R China

[2] Shenyang Agr Univ, Dept Pesticide Sci, Plant Protect Coll, Shenyang 110866, Liaoning, Peoples R China

[3] Chiba Univ, Grad Sch Adv Integrat Sci, Dept Nanobiol, Chiba 2718510, Japan

[4] Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2014年 / 11卷 / 07期

基金：

中国国家自然科学基金; 日本学术振兴会;

关键词：

Synthesis; 5-Phenyl-2-furan; Carvacrol and thymol derivatives; Antitumor activity; Antifungal activity; ESSENTIAL OILS; N; N'-DIACYLHYDRAZINE DERIVATIVES; FUNGICIDAL ACTIVITY; ANTIMICROBIAL ACTIVITY; BACILLUS-CEREUS; FURAN; HYDRAZINE; EFFICACY; EUGENOL; 3D-QSAR;

D O I：

10.2174/1570180811666140220005252

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel carvacrol and thymol derivatives containing 5-phenyl-2-furan were synthesized. The antitumor tests showed that the title compounds exhibited promising activity against Bel-7402 and KB. The fungicidal tests showed that most of the title compounds had a considerable effect on the selected fungi. Generally the bioactivity of the carvacrol and its derivatives were better than that of the thymol and its derivatives. The substituted groups on the ortho- and para-positions gave better activity than that of ones on the meta-position.

引用

页码：877 / 885

页数：9

共 29 条

[1]

Alan D.B., 2012, CHEM REV, V112, P3641

[2] Acaricidal activities of Santolina africana and Hertia cheirifolia essential oils against the two-spotted spider mite (Tetranychus urticae) [J].

Attia, Sabrine ;

Grissa, Kaouthar L. ;

Mailleux, Anne C. ;

Heuskin, Stephanie ;

Lognay, Georges ;

Hance, Thierry .

PEST MANAGEMENT SCIENCE, 2012, 68 (07) :1069-1076

[3]

Baser KHC, 2008, CURR PHARM DESIGN, V14, P3106, DOI 10.2174/138161208786404227

[4]

Chen J., 1991, CHINESE CHEM LETT, V2, P433

[5] Synthesis and bioactivity of novel N,N′-diacylhydrazine derivatives containing furan(I) [J].

Cui Zi-Ning ;

Huang Juan ;

Li Ying ;

Ling Yun ;

Yang Xin-Ling ;

Chen Fu-Heng .

CHINESE JOURNAL OF CHEMISTRY, 2008, 26 (05) :916-922

[6]

Cui ZN, 2008, ACTA CHIM SINICA, V66, P1417

[7]

Cui ZN, 2007, CHINESE J ORG CHEM, V27, P1300

[8] Synthesis and Fungicidal Activity of Novel 2,5-Disubstituted-1,3,4-oxadiazole Derivatives [J].

Cui, Zi-Ning ;

Shi, Yan-Xia ;

Zhang, Li ;

Ling, Yun ;

Li, Bao-Ju ;

Nishida, Yoshihiro ;

Yang, Xin-Ling .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (47) :11649-11656

[9] Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan [J].

Cui, Zi-Ning ;

Shi, Yan-Xia ;

Cui, Jing-Rong ;

Ling, Yun ;

Li, Bao-Ju ;

Yang, Xin-Ling .

CHEMICAL BIOLOGY & DRUG DESIGN, 2012, 79 (01) :121-127

[10] Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety [J].

Cui, Zining ;

Yang, Xinling ;

Shi, Yanxia ;

Uzawa, Hirotaka ;

Cui, Jingrong ;

Dohi, Hirofumi ;

Nishida, Yoshihiro .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (23) :7193-7196

← 1 2 3 →