Mitochondrion-Specific Live-Cell Bioprobe Operated in a Fluorescence Turn-On Manner and a Well-Designed Photoactivatable Mechanism

被引：91
作者：
Gu, Xinggui [1 ,2 ,3 ,4 ,5 ]
Zhao, Engui [1 ,2 ,3 ,4 ,5 ]
Lam, Jacky W. Y. [1 ,2 ,3 ,4 ,5 ]
Peng, Qian [6 ]
Xie, Yujun [6 ]
Zhang, Yilin [2 ,3 ,4 ,5 ]
Wong, Kam Sing [2 ,3 ,4 ,5 ]
Sung, Herman H. Y. [2 ,3 ,4 ,5 ]
Williams, Ian D. [2 ,3 ,4 ,5 ]
Tang, Ben Zhong [1 ,2 ,3 ,4 ,5 ,7 ]
机构：
[1] HKUST Shenzhen Res Inst, 9 Yuexing 1st RD,South Area,Hitech Pk, Shenzhen 518057, Peoples R China
[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
[3] Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
[4] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Div Life Sci, Kowloon, Hong Kong, Peoples R China
[5] Hong Kong Univ Sci & Technol, Div Biomed Engn, Kowloon, Hong Kong, Peoples R China
[6] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Beijing 100190, Peoples R China
[7] S China Univ Technol, State Key Lab Luminescent Mat & Device, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, Guangzhou 51640, Guangdong, Peoples R China
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 44期
关键词：
AGGREGATION-INDUCED EMISSION; INTRAMOLECULAR CHARGE-TRANSFER; FLUOROPHORES; PROTEINS; ACTIVATION; CHEMISTRY; DYES;
D O I：
10.1002/adma.201503751
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel mitochondrion-specific live-cell fluorescence turn-on photoactivatable bioprobe, named o-TPP3M, is designed and readily prepared, operating in a new photoactivatable mechanism based on a twisted intramolecular charge-transfer effect, the restriction of intramolecular rotations, and photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior, a large signal-to-background ratio, and no cytotoxicity to living cells, providing a promising candidate for varied bioresearch.
引用
收藏
页码：7093 / 7100
页数：8
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