Multifaceted role of matrix metalloproteinases (MMPs)

被引：151
作者：
Singh, Divya [1 ]
Srivastava, Sanjeev K. [2 ]
Chaudhuri, Tapas K. [2 ]
Upadhyay, Ghanshyam [1 ]
机构：
[1] CUNY City Coll, Dept Biol, Marshak Bldg,160 Convent Ave, New York, NY 10031 USA
[2] Univ North Bengal, Dept Zool, Cellular Immunol Lab, Siliguri 734013, India
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2015年 / 2卷
关键词：
MMP2; MMP9; neurodegenerative disorders; Japanese encephalitis; glaucoma; JAPANESE ENCEPHALITIS-VIRUS; DIFFERENT BRAIN-REGIONS; CENTRAL-NERVOUS-SYSTEM; TISSUE INHIBITORS; AMYLOID-BETA; INTRAOCULAR-PRESSURE; MOLECULAR-BIOLOGY; GELATINASE-B; MOUSE-BRAIN; STEM-CELLS;
D O I：
10.3389/fmolb.2015.00019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of alpha-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Japanese encephalitis (JE), and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under-investigated. The present review summarizes the role of MMPs in neurodegeneration with a particular emphasis on PD, AD, JE, and Glaucoma.
引用
收藏
页数：5
相关论文
共 50 条
  • [31] The immunomodulatory role of matrix metalloproteinases in colitis-associated cancer
    He, Luying
    Kang, Qianming
    Chan, Ka Iong
    Zhang, Yang
    Zhong, Zhangfeng
    Tan, Wen
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [32] Inhibition of Matrix Metalloproteinases (MMPs) as a Potential Strategy to Ameliorate Hypertension-Induced Cardiovascular Alterations
    Castro, Michele M.
    Tanus-Santos, Jose E.
    CURRENT DRUG TARGETS, 2013, 14 (03) : 335 - 343
  • [33] Matrix metalloproteinases (MMPs): Modern molecular markers of open-angle glaucoma diagnosis and therapy
    Kowalski, Michal
    Walczak, Anna
    Majsterek, Ireneusz
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2008, 62 : 582 - 592
  • [34] Matrix Metalloproteinases and Glaucoma
    Kim, Moo Hyun
    Lim, Su-Ho
    BIOMOLECULES, 2022, 12 (10)
  • [35] The Role Matrix Metalloproteinases in the Production of Aortic Aneurysm
    Rabkin, Simon W.
    MATRIX METALLOPROTEINSES AND TISSUE REMODELING IN HEALTH AND DISEASE: CARDIOVASCULAR REMODELING, 2017, 147 : 239 - 265
  • [36] Role of matrix Metalloproteinases in pituitary adenoma invasion
    Yang Chengxian
    Bao Xinjie
    Wang Renzhi
    Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China
    中华神经外科杂志（英文）, 2018, 4 (01) : 33 - 38
  • [37] Matrix metalloproteinases: their functional role in lung cancer
    Merchant, Neha
    Nagaraju, Ganji Purnachandra
    Rajitha, Balney
    Lammata, Saipriya
    Jella, Kishore Kumar
    Buchwald, Zachary S.
    Lakka, Sajani S.
    Ali, Arif N.
    CARCINOGENESIS, 2017, 38 (08) : 766 - 780
  • [38] Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms
    Zhang, Xiaoran
    Ares, William J.
    Taussky, Philipp
    Ducruet, Andrew F.
    Grandhi, Ramesh
    NEUROSURGICAL FOCUS, 2019, 47 (01)
  • [39] The role of matrix metalloproteinases in infectious corneal ulcers
    Garcia-Lopez, Celia
    Rodriguez-Calvo-de-Mora, Marina
    Borroni, Davide
    Sanchez-Gonzalez, Jose-Maria
    Romano, Vito
    Rocha-de-Lossada, Carlos
    SURVEY OF OPHTHALMOLOGY, 2023, 68 (05) : 929 - 939
  • [40] Role of matrix Metalloproteinases in pituitary adenoma invasion
    Yang C.
    Bao X.
    Wang R.
    Chinese Neurosurgical Journal, 4 (1)
12345