Multifaceted role of matrix metalloproteinases (MMPs)

被引：150
|
作者：
Singh, Divya [1 ]
Srivastava, Sanjeev K. [2 ]
Chaudhuri, Tapas K. [2 ]
Upadhyay, Ghanshyam [1 ]
机构：
[1] CUNY City Coll, Dept Biol, Marshak Bldg,160 Convent Ave, New York, NY 10031 USA
[2] Univ North Bengal, Dept Zool, Cellular Immunol Lab, Siliguri 734013, India
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2015年 / 2卷
关键词：
MMP2; MMP9; neurodegenerative disorders; Japanese encephalitis; glaucoma; JAPANESE ENCEPHALITIS-VIRUS; DIFFERENT BRAIN-REGIONS; CENTRAL-NERVOUS-SYSTEM; TISSUE INHIBITORS; AMYLOID-BETA; INTRAOCULAR-PRESSURE; MOLECULAR-BIOLOGY; GELATINASE-B; MOUSE-BRAIN; STEM-CELLS;
D O I：
10.3389/fmolb.2015.00019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of alpha-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Japanese encephalitis (JE), and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under-investigated. The present review summarizes the role of MMPs in neurodegeneration with a particular emphasis on PD, AD, JE, and Glaucoma.
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页数：5
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