Multifaceted role of matrix metalloproteinases (MMPs)

被引：153
作者：
Singh, Divya [1 ]
Srivastava, Sanjeev K. [2 ]
Chaudhuri, Tapas K. [2 ]
Upadhyay, Ghanshyam [1 ]
机构：
[1] CUNY City Coll, Dept Biol, Marshak Bldg,160 Convent Ave, New York, NY 10031 USA
[2] Univ North Bengal, Dept Zool, Cellular Immunol Lab, Siliguri 734013, India
来源：
FRONTIERS IN MOLECULAR BIOSCIENCES | 2015年 / 2卷
关键词：
MMP2; MMP9; neurodegenerative disorders; Japanese encephalitis; glaucoma; JAPANESE ENCEPHALITIS-VIRUS; DIFFERENT BRAIN-REGIONS; CENTRAL-NERVOUS-SYSTEM; TISSUE INHIBITORS; AMYLOID-BETA; INTRAOCULAR-PRESSURE; MOLECULAR-BIOLOGY; GELATINASE-B; MOUSE-BRAIN; STEM-CELLS;
D O I：
10.3389/fmolb.2015.00019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of alpha-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Japanese encephalitis (JE), and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under-investigated. The present review summarizes the role of MMPs in neurodegeneration with a particular emphasis on PD, AD, JE, and Glaucoma.
引用
收藏
页数：5
相关论文
共 56 条
[1]   The Cell and Molecular Biology of Glaucoma: Axonopathy and the Brain [J].
Calkins, David J. ;
Horner, Philip J. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (05) :2482-2484
[2]   DIVERSE ROLES OF MATRIX METALLOPROTEINASES AND TISSUE INHIBITORS OF METALLOPROTEINASES IN NEUROINFLAMMATION AND CEREBRAL ISCHEMIA [J].
Candelario-Jalil, E. ;
Yang, Y. ;
Rosenberg, G. A. .
NEUROSCIENCE, 2009, 158 (03) :983-994
[3]   A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells [J].
Choi, D. H. ;
Kim, E. -M. ;
Son, H. J. ;
Joh, T. H. ;
Kim, Y. S. ;
Kim, D. ;
Beal, M. F. ;
Hwang, O. .
JOURNAL OF NEUROCHEMISTRY, 2008, 106 (01) :405-415
[4]   Role of Matrix Metalloproteinase 3-mediated α-Synuclein Cleavage in Dopaminergic Cell Death [J].
Choi, Dong-Hee ;
Kim, Youn-Jung ;
Kim, Young-Gun ;
Joh, Tong H. ;
Beal, M. Flint ;
Kim, Yoon-Seong .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (16) :14168-14177
[5]   MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson's Disease [J].
Chung, Young Cheul ;
Kim, Yoon-Seong ;
Bok, Eugene ;
Yune, Tae Young ;
Maeng, Sungho ;
Jin, Byung Kwan .
MEDIATORS OF INFLAMMATION, 2013, 2013
[6]   MMPs in the Trabecular Meshwork: Promising Targets for Future Glaucoma Therapies? [J].
De Groef, Lies ;
Van Hove, Inge ;
Dekeyster, Eline ;
Stalmans, Ingeborg ;
Moons, Lieve .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (12) :7756-7763
[7]   HUMAN SKIN COLLAGENASE . ISOLATION AND MECHANISM OF ATTACK ON COLLAGEN MOLECULE [J].
EISEN, AZ ;
JEFFREY, JJ ;
GROSS, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 151 (03) :637-+
[8]   Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets [J].
Ethell, Iryna M. ;
Ethell, Douglas W. .
JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (13) :2813-2823
[9]   Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas [J].
Forsyth, PA ;
Wong, H ;
Laing, TD ;
Rewcastle, NB ;
Morris, DG ;
Muzik, H ;
Leco, KJ ;
Johnston, RN ;
Brasher, PMA ;
Sutherland, G ;
Edwards, DR .
BRITISH JOURNAL OF CANCER, 1999, 79 (11-12) :1828-1835
[10]   Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease [J].
Fujioka, Hiromi ;
Dairyo, Yusuke ;
Yasunaga, Kei-Ichiro ;
Emoto, Kazuo .
BIOCHEMISTRY RESEARCH INTERNATIONAL, 2012, 2012
123456