SMAD destruction turns off signalling

被引：10

作者：

Heldin, CH

ten Dijke, P

机构：

[1] Ludwig Inst Canc Res, S-75124 Uppsala, Sweden

[2] Netherlands Canc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 08期

关键词：

D O I：

10.1038/70223

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SMAD proteins are key signal-transduction molecules whose activity must be tightly regulated. SMADs can be activated by phosphorylation, and at least one, Smad2, can be deactivated by degradation by protein-crunching proteasomes in the nucleus.

引用

页码：E195 / E197

页数：3

共 6 条

[1] The ubiquitin-proteasome pathway: on protein death and cell life [J].

Ciechanover, A .

EMBO JOURNAL, 1998, 17 (24) :7151-7160

[2] Substrate targeting in the ubiquitin system [J].

Laney, JD ;

Hochstrasser, M .

CELL, 1999, 97 (04) :427-430

[3] Ubiquitin-dependent degradation of TGF-β-activated Smad2 [J].

Lo, RS ;

Massagué, J .

NATURE CELL BIOLOGY, 1999, 1 (08) :472-478

[4]

PIEK E, IN PRESS FASEB J

[5] SnoN and Ski protooncoproteins ave rapidly degraded in response to transforming growth factor β signaling [J].

Sun, Y ;

Liu, XD ;

Ng-Eaton, E ;

Lodish, HF ;

Weinberg, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12442-12447

[6] A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation [J].

Zhu, HT ;

Kavsak, P ;

Abdollah, S ;

Wrana, JL ;

Thomsen, GH .

NATURE, 1999, 400 (6745) :687-693

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