Inhibition of macrophage migration inhibitory factor prevents thyroid dysfunction in pregnant rats with acute pancreatitis

被引：6

作者：

Chen, Ying ^{[1
]}

Wang, Chen-yang ^{[1
]}

Zhao, Liang ^{[1
,3
]}

Hong, Yu-pu ^{[1
,4
]}

Zhang, Xiao-yi ^{[5
]}

Mei, Fang-chao ^{[1
]}

Zhou, Yu ^{[1
]}

Guo, Wen-yi ^{[1
]}

Shi, Qiao ^{[2
]}

Zhao, Kai-liang ^{[1
]}

Chen, Chen ^{[1
]}

Yu, Jia ^{[1
]}

Wang, Wei-xing ^{[1
]}

机构：

[1] Wuhan Univ, Dept Gen Surg, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China

[2] Wuhan Univ, Dept Pancreat Surg, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[3] Key Lab Hubei Prov Digest Syst Dis, Wuhan 430060, Hubei, Peoples R China

[4] Wuhan Univ, Cent Lab, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[5] Wuhan Univ, Dept Crit Care Med, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 87卷

基金：

中国国家自然科学基金;

关键词：

Acute pancreatitis; Pregnancy; Thyroid dysfunction; Macrophage migration inhibitory factor; TAUTOMERASE ACTIVE-SITE; MODEL; FETAL; INJURY; MIF; INFLAMMATION; SURVIVAL; TARGET; CELLS; ISO-1;

D O I：

10.1016/j.intimp.2020.106771

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute pancreatitis during pregnancy (APIP) rarely occurs but may lead to preterm delivery and be associated with high fetal mortality. Macrophage migration inhibitory factor (MIF) participates in various inflammatory diseases as a pro-inflammatory cytokine. In this study, we aimed to explore the effects of (S, R) 3 (4 hydroxypheny1)-4, 5dihydro-5-isoxazole acetic methyl ester (ISO-1), an inhibitor of MIF, on maternal thyroid injury associated with APIP and its potential mechanisms in a pregnant rat model. APIP model was induced by retrograde injection of sodium taurocholate. ISO-1 was injected intraperitoneally 30 min before model establishment. The severity of pancreatitis was assessed by levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 of maternal serum as well as histopathological score. Thyroid injury was determined by free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid histopathological score. Levels of MIF in maternal serum and the expression of MIF, CD68, CD3 and intercellular cell adhesion molecule-1 (ICAM-1) as well as oxidative stress status in maternal thyroid tissues were detected. Ultrastructure of maternal thyroid tissues was observed by transmission electron microscope. Thyroid injuries occurred in APIP and the lesions were attenuated with the pretreatment of ISO-1. Moreover, ISO-1 reduced the expression of MIF, attenuated the activations of CD68, CD3, ICAM-1 while improved oxidative stress status in maternal thyroid. Our research suggested a protective role of ISO-1 on thyroid injury and endocrine disorder during APIP, which may be associated with the inhibition of biological functions of MIF.

引用

页数：8

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