Allergy and autoimmunity: Parallels and dissimilarity The Yin and Yang of Immunopathology

被引：17

作者：

Bartunkova, Jirina ^{[1
]}

Kayserova, Jana ^{[1
]}

Shoenfeld, Yehuda ^{[2
]}

机构：

[1] Charles Univ Prague, Dept Immunol, Fac Med 2, Univ Hosp Motol, Prague 15006 5, Czech Republic

[2] Tel Aviv Univ, Ctr Autoimmune Dis, Dept Med B, Sheba Med Ctr, IL-52621 Tel Hashomer, Israel

来源：

AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 04期

关键词：

Autoimmune disease; Allergy; HLA; Cytokines; Autoantigens; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ATOPIC-DERMATITIS; IMMUNOGLOBULIN-E; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; SJOGRENS-SYNDROME; DISEASES; ASTHMA; IGE; CHILDREN;

D O I：

10.1016/j.autrev.2008.09.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The etiopathogenesis of allergy and autoimmune diseases is caused by genetic and acquired (environmental) factors, which might be common to both immmunopathologies. Genetic factors play an important role in the development and process of immunopathological diseases. Several studies suggest a close relation between gene polymorphism of HLA and cytokines and development of autoimmunity and allergy. Certain gene polymorphisms act as risk or as protective factors. The infection also plays an important role in the induction of allergy and autoimmunity - as a trigger or as a protective factor. Moreover, similar clinical manifestations of both immunopathologies could result in diagnostic problems. This review summarizes the linkage of mechanisms of etiopathogenesis, clinical manifestations and therapeutic strategy between allergic and autoimmune diseases. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：302 / 308

页数：7

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