Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins (Carassius auratus)

被引：33

作者：

Zaccaroni, A. ^{[1
]}

Gamberoni, M. ^{[2
]}

Mandrioli, L. ^{[1
]}

Sirri, R. ^{[1
]}

Mordenti, O. ^{[2
]}

Scaravelli, D. ^{[1
]}

Sarli, G. ^{[1
]}

Parmeggiani, A. ^{[2
]}

机构：

[1] Univ Bologna, Dept Vet Publ Hlth & Anim Pathol, I-40064 Bologna, Italy

[2] Univ Bologna, Dept Vet Morphophysiol & Anim Prod, I-40064 Bologna, Italy

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2009年 / 407卷 / 10期

关键词：

Nonylphenol; Carassius auratus; Vitellogenin; Thyroid hormones; Histology; GONADOTROPIN-RELEASING-HORMONE; ENDOCRINE-DISRUPTING CHEMICALS; NONYLPHENOL ETHOXYLATES; JAPANESE MEDAKA; RAINBOW-TROUT; GONADAL DEVELOPMENT; DIETARY EXPOSURE; GENE-EXPRESSION; BISPHENOL-A; FISH;

D O I：

10.1016/j.scitotenv.2009.01.036

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nonylphenol, an estrogenic-like compound, can induce vitellogenin synthesis in males and immature Teleostean species, but little is known about its effects on thyroid hormones balance. The present study evaluated the potential effects of a single acute exposure to nonylphenol (i.p. injected) on the thyroid and reproductive axis of 250 shubunkins (Carassius auratus). Plasma levels of thyroid hormones were quantified immunoenzymatically by ELISA assay. Nonylphenol induced a significant decrease of thyroxin levels, whereas no effect on triiodothyronine concentrations was detected. No histopathological changes were detected in thyroid or testes. The toxicological data confirmed that nonylphenol exerts an estrogenic effect on male fish. In addition, nonylphenol was suspected to inhibit the thyroid hormones balance, suggesting the thyroid should be included among the other endocrine glands susceptible to endocrine disruption. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：3301 / 3306

页数：6

共 55 条

[1] Effects of long-term nonylphenol exposure on gonadal development and biomarkers of estrogenicity in juvenile rainbow trout (Oncorhynchus mykiss) [J].