Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity

Phytochemical investigation of ethanolic extract from the fruits of Schisandra chinensis led to the isolation of four new sesquiterpenes (1-4); their structures were determined by a combination of NMR (1D and 2D) and MS spectroscopic techniques. In addition, all these isolates were screened for their cytotoxic activities against MCF-7, Caco-2, Hela, Lncap, Hep G2 and MDA-MB231 cancer cell lines. Results indicated that compounds 2 and 3 displayed potent cytotoxic activity against Caco2 cell lines with IC50 values of 17.10 mu g/mM and 16.46 mu g/mM, respectively. (C) 2014 Elsevier B.V. All rights reserved.