Enantiomeric Separation of Azole Antifungal Compounds using Chromatographic and Electrophoretic Techniques: A Mini Review

被引：5

作者：

Azhari, Nurul Raihana Binti ^{[1
]}

Hui, Boon Yih ^{[1
]}

Zain, Nur Nadhirah Mohamad ^{[1
]}

Suah, Fail Bukhari Mohd ^{[2
]}

Mohamad, Sharifah ^{[3
,4
]}

Yahaya, Noorfatimah ^{[1
]}

Raoov, Muggundha ^{[3
,4
]}

机构：

[1] Univ Sains Malaysia, Adv Med & Dent Inst AMDI, Integrat Med Cluster, George Town 13200, Malaysia

[2] Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia

[3] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Dept Chem, Fac Sci, Ctr Ion Liquids, Kuala Lumpur 50603, Malaysia

来源：

SAINS MALAYSIANA | 2020年 / 49卷 / 11期

关键词：

Antifungal compounds; azole; capillary electrophoresis; chiral separation; chromatographic analysis; CHIRAL STATIONARY PHASES; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PERFORMANCE LIQUID-CHROMATOGRAPHY; AMINO-ACID ENANTIOMERS; TRIAZOLE FUNGICIDES; CAPILLARY-ELECTROPHORESIS; STEREOISOMERS; ENANTIOSELECTIVE DETERMINATION; SIMULTANEOUS ENANTIOSEPARATION; KETOCONAZOLE ENANTIOMERS;

D O I：

10.17576/jsm-2020-4911-09

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The separation of azole antifungal chiral compounds has gaining much interests since 1980's as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed analytical methods such as preparation techniques and optimization parameters towards the enantioseparation performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral separation, particularly for azole compounds are provided accordingly.

引用

页码：2699 / 2714

页数：16

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