Principles and Properties of Eukaryotic mRNPs

被引：267
作者：
Mitchell, Sarah F. [1 ]
Parker, Roy [1 ,2 ]
机构：
[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80303 USA
[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80303 USA
来源：
MOLECULAR CELL | 2014年 / 54卷 / 04期
关键词：
RNA-BINDING PROTEIN; MIRNA-MEDIATED REPRESSION; BICOID MESSENGER-RNA; TRANSLATION INITIATION; STRESS GRANULES; QUALITY-CONTROL; GLOBAL ANALYSIS; HNRNP A1; DEGRADATION; DOMAINS;
D O I：
10.1016/j.molcel.2014.04.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proper processing, export, localization, translation, and degradation of mRNAs are necessary for regulation of gene expression. These processes are controlled by mRNA-specific regulatory proteins, noncoding RNAs, and core machineries common to most mRNAs. These factors bind the mRNA in large complexes known as messenger ribonucleoprotein particles (mRNPs). Herein, we review the components of mRNPs, how they assemble and rearrange, and how mRNP composition differentially affects mRNA biogenesis, function, and degradation. We also describe how properties of the mRNP "interactome'' lead to emergent principles affecting the control of gene expression.
引用
收藏
页码：547 / 558
页数：12
相关论文
共 95 条
  • [61] RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence
    Masliah, Gregoire
    Barraud, Pierre
    Allain, Frederic H-T
    [J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (11) : 1875 - 1895
  • [62] Circular RNAs are a large class of animal RNAs with regulatory potency
    Memczak, Sebastian
    Jens, Marvin
    Elefsinioti, Antigoni
    Torti, Francesca
    Krueger, Janna
    Rybak, Agnieszka
    Maier, Luisa
    Mackowiak, Sebastian D.
    Gregersen, Lea H.
    Munschauer, Mathias
    Loewer, Alexander
    Ziebold, Ulrike
    Landthaler, Markus
    Kocks, Christine
    le Noble, Ferdinand
    Rajewsky, Nikolaus
    [J]. NATURE, 2013, 495 (7441) : 333 - 338
  • [63] MRNA turnover
    Mitchell, P
    Tollervey, D
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (03) : 320 - 325
  • [64] Global analysis of yeast mRNPs
    Mitchell, Sarah F.
    Jain, Saumya
    She, Meipei
    Parker, Roy
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (01) : 127 - U161
  • [65] Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability
    Mukherjee, Neelanjan
    Corcoran, David L.
    Nusbaum, Jeffrey D.
    Reid, David W.
    Georgiev, Stoyan
    Hafner, Markus
    Ascano, Manuel, Jr.
    Tuschl, Thomas
    Ohler, Uwe
    Keene, Jack D.
    [J]. MOLECULAR CELL, 2011, 43 (03) : 327 - 339
  • [66] MicroRNAs can generate thresholds in target gene expression
    Mukherji, Shankar
    Ebert, Margaret S.
    Zheng, Grace X. Y.
    Tsang, John S.
    Sharp, Phillip A.
    van Oudenaarden, Alexander
    [J]. NATURE GENETICS, 2011, 43 (09) : 854 - U60
  • [67] Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5′ to 3′ and 3′ to 5′
    Mullen, Thomas E.
    Marzluff, William F.
    [J]. GENES & DEVELOPMENT, 2008, 22 (01) : 50 - 65
  • [68] Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis
    Nakamura, A
    Sato, K
    Hanyu-Nakamura, K
    [J]. DEVELOPMENTAL CELL, 2004, 6 (01) : 69 - 78
  • [69] Computational analysis of miRNA-mediated repression of translation: Implications for models of translation initiation inhibition
    Nissan, Tracy
    Parker, Roy
    [J]. RNA, 2008, 14 (08) : 1480 - 1491
  • [70] The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast
    Olivas, W
    Parker, R
    [J]. EMBO JOURNAL, 2000, 19 (23) : 6602 - 6611
12345678910