Principles and Properties of Eukaryotic mRNPs

被引：279

作者：

Mitchell, Sarah F. ^{[1
]}

Parker, Roy ^{[1
,2
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80303 USA

[2] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80303 USA

来源：

MOLECULAR CELL | 2014年 / 54卷 / 04期

关键词：

RNA-BINDING PROTEIN; MIRNA-MEDIATED REPRESSION; BICOID MESSENGER-RNA; TRANSLATION INITIATION; STRESS GRANULES; QUALITY-CONTROL; GLOBAL ANALYSIS; HNRNP A1; DEGRADATION; DOMAINS;

D O I：

10.1016/j.molcel.2014.04.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proper processing, export, localization, translation, and degradation of mRNAs are necessary for regulation of gene expression. These processes are controlled by mRNA-specific regulatory proteins, noncoding RNAs, and core machineries common to most mRNAs. These factors bind the mRNA in large complexes known as messenger ribonucleoprotein particles (mRNPs). Herein, we review the components of mRNPs, how they assemble and rearrange, and how mRNP composition differentially affects mRNA biogenesis, function, and degradation. We also describe how properties of the mRNP "interactome'' lead to emergent principles affecting the control of gene expression.

引用

页码：547 / 558

页数：12

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