Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

被引：337

作者：

Sims, Natalie A. ^{[1
]}

Gooi, Jonathan H.

机构：

[1] St Vincents Inst, Fitzroy, Vic 3065, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2008年 / 19卷 / 05期

关键词：

Osteoblast; Osteoclast; Osteocyte; Coupling; Bone remodeling;

D O I：

10.1016/j.semcdb.2008.07.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The dynamic nature of the skeleton is achieved by a process called "remodeling" which involves the coordinated actions of osteoclasts, osteoblasts, osteocytes within the bone matrix and osteoblast-derived lining cells that cover the surface of bone. Remodeling commences with signals that initiate osteoclast formation followed by osteoclast-mediated bone resorption, a reversal period, and then a long period of bone matrix formation mediated by osteoblasts, followed by mineralisation of the matrix. This review will discuss each of these steps with particular emphasis on the communication pathways between each cell type involved and the roles of ephrins, sclerostin, RANKL and PTHrP. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：444 / 451

页数：8

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