Chronic Inflammatory Diseases: Are We Ready for Microbiota-based Dietary Intervention?

被引：15

作者：

Viennois, Emilie ^{[1
]}

Gewirtz, Andrew T. ^{[1
]}

Chassaing, Benoit ^{[1
,2
]}

机构：

[1] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA

[2] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA

来源：

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2019年 / 8卷 / 01期

关键词：

Microbiota; Inflammation; Diet; Personalized Medicine; GUT MICROBIOTA; CROHNS-DISEASE; BOWEL-DISEASE; ESCHERICHIA-COLI; ELEMENTAL DIET; HOST GENOME; TRANSPLANTATION; EMULSIFIERS; DYSBIOSIS; MUCOSA;

D O I：

10.1016/j.jcmgh.2019.02.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The last 15 years have witnessed the emergence of a new field of research that focuses on the roles played by the intestinal microbiota in health and disease. This research field has produced accumulating evidence indicating that dysregulation of host-microbiota interactions contributes to a range of chronic inflammatory diseases, including inflammatory bowel diseases, colorectal cancer, and metabolic syndrome. Although dysregulation of the microbiota can take complex forms, in some cases, specific bacterial species that can drive specific clinical outcomes have been identified. Among the numerous factors influencing the intestinal microbiota composition, diet is a central actor, wherein numerous dietary factors can beneficially or detrimentally impact the host/microbiota relationship. This review will highlight recent literature that has advanced understanding of microbiota-diet-disease interplay, with a central focus on the following question: Are we ready to use intestinal microbiota composition-based personalized dietary interventions to treat chronic inflammatory diseases?

引用

页码：61 / 71

页数：11

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