Natural History of Localized and Locally Advanced Atypical Lung Carcinoids after Complete Resection: A Joined French-Italian Retrospective Multicenter Study

被引：12

作者：

Marciello, Francesca ^{[1
]}

Mercier, Olaf ^{[2
]}

Ferolla, Piero ^{[3
]}

Scoazec, Jean-Yves ^{[4
]}

Filosso, Pier Luigi ^{[5
]}

Chapelier, Alain ^{[6
]}

Guggino, Gianluca ^{[7
]}

Monaco, Roberto ^{[8
]}

Grimaldi, Franco ^{[9
]}

Pizzolitto, Stefano ^{[10
]}

Guigay, Joel ^{[11
]}

de latour, Bertrand Richard ^{[12
]}

Giuffrida, Dario ^{[13
]}

Longchampt, Elisabeth ^{[14
]}

de Montpreville, Vincent Thomas ^{[15
]}

Fadel, Elie ^{[2
]}

Colao, Annamaria ^{[1
]}

Planchard, David ^{[16
]}

Papotti, Mauro ^{[17
]}

Faggiano, Antongiulio ^{[18
]}

Baudin, Eric ^{[19
]}

机构：

[1] Univ Naples Federico II, Div Endocrinol, Dept Clin Med & Surg, Naples, Italy

[2] Marie Lannelongue Hosp, Dept Thorac & Vasc Surg, Le Plessis Robinson, France

[3] Umbria Reg Canc Network, ENETS Ctr Excellence, Multidisciplinary Grp Diag & Therapy Neuroendocri, Perugia, Italy

[4] Inst Gustave Roussy, Dept Pathol, Villejuif, France

[5] Univ Turin, Dept Thorac Surg, Turin, Italy

[6] Foch Hosp, Dept Thorac Surg, Suresnes, France

[7] Antonio Cardarelli Hosp, Dept Thorac Surg, Naples, Italy

[8] Antonio Cardarelli Hosp, Dept Pathol, Naples, Italy

[9] Santa Maria della Misericordia Univ Hosp, Endocrinol & Metab Dis Unit, Udine, Italy

[10] Santa Maria della Misericordia Univ Hosp, Pathol, Udine, Italy

[11] Ctr Antoine Lacassagne, Dept Med Oncol, Nice, France

[12] Univ Rennes, Univ Hosp Rennes Pontchaillou, Dept Thorac & Cardiovasc Surg, Rennes, France

[13] Mediterranean Inst Oncol, Dept Med Oncol, Viagrande, Italy

[14] Foch Hosp, Dept Pathol, Suresnes, France

[15] Marie Lannelongue Hosp, Dept Pathol, Le Plessis Robinson, France

[16] Inst Gustave Roussy, Dept Med Oncol, Villejuif, France

[17] Univ Turin, Dept Pathol, Turin, Italy

[18] IRCCS Naples Fdn G Pascale, Ist Nazl Studio & Cura Tumori, Thyroid & Parathyroid Surg Unit, Naples, Italy

[19] Inst Gustave Roussy, Dept Nucl Med & Endocrine Tumors, 39 Rue Camille Desmoulins, FR-94805 Villejuif, France

来源：

NEUROENDOCRINOLOGY | 2018年 / 106卷 / 03期

关键词：

Atypical carcinoids; Neuroendocrine tumor; Recurrence; Surgery; Survival; GASTROENTEROPANCREATIC NEUROENDOCRINE NEOPLASMS; PROGNOSTIC-FACTORS; PULMONARY CARCINOIDS; SURGICAL-MANAGEMENT; TUMORS; CLASSIFICATION; EXPERIENCE; SURVIVAL; GRADE; GUIDELINES;

D O I：

10.1159/000480015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The natural history and the best modality of follow-up of atypical lung carcinoids (AC) remain ill defined. The aim of this study was to analyze recurrence-free survival (RFS) after complete resection (R0) of stage I-III pulmonary AC. Secondary objectives were prognostic parameters, the location of recurrences, and the modality of follow-up. Methods: A retrospective review of 540 charts of AC patients treated between 1998 and 2008 at 10 French and Italian centers with experience in lung neuroendocrine tumor management was undertaken. The exclusion criteria were MEN1-related tumor, history of another cancer, referral after tumor relapse, and being lost to follow-up. A central pathological review was performed in each country. Results: Sixty-two patients were included. After a median follow-up time of 91 months (mean 85, range 6-165), 35% of the patients experienced recurrence: 16% were regional recurrences and 19% were distant metastases. Median RFS was not reached. The 1-, 3-, and 5-year RFS rate was 90, 79, and 68%, respectively. In univariate analysis, lymph node involvement (p = 0.0001), stage (p = 0.0001), mitotic count (p = 0.004), and type of surgery (p = 0.043) were significantly associated with RFS. In multivariate analysis, lymph node involvement was significantly associated with RFS (HR 95% CI: 0.000-0.151; p = 0.004). During follow-up, somatostatin receptor scintigraphy, fibroscopy, and abdominal examination results were available for 22, 12, and 25 patients, respectively. The median time interval for imaging follow-up was 10 months. Conclusions: After complete resection of AC, recurrences were observed mostly within the first 5 years of follow-up, within bronchi, mediastinal nodes, the liver, and bones. In R0 patients, lymph node involvement could help to stratify followup intervals. Suboptimal imaging is evidenced. (c) 2017 S. Karger AG, Basel

引用

页码：264 / 273

页数：10

共 43 条

[21] Characteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms [J].

Heetfeld, M. ;

Chougnet, C. N. ;

Olsen, I. H. ;

Rinke, A. ;

Borbath, I. ;

Crespo, G. ;

Barriuso, J. ;

Pavel, M. ;

O'Toole, D. ;

Walter, T. .

[22] Somatostatin Receptors in Bronchopulmonary Neuroendocrine Neoplasms: New Diagnostic, Prognostic, and Therapeutic Markers [J].

Kaemmerer, Daniel ;

Specht, Elisa ;

Saenger, Joerg ;

Wirtz, Ralph Markus ;

Sayeg, Manal ;

Schulz, Stefan ;

Lupp, Amelie .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2015, 100 (03) :831-840

[23] A Comparison of 68Ga-DOTATATE and 18F-FDG PET/CT in Pulmonary Neuroendocrine Tumors [J].

Kayani, Irfan ;

Conry, Brendon G. ;

Groves, Ashley M. ;

Win, Thida ;

Dickson, John ;

Caplin, Martyn ;

Bomanji, Jamshed B. .

JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (12) :1927-1932

[24] Consensus Guidelines for the Management and Treatment of Neuroendocrine Tumors [J].

Kunz, Pamela L. ;

Reidy-Lagunes, Diane ;

Anthony, Lowell B. ;

Bertino, Erin M. ;

Brendtro, Kari ;

Chan, Jennifer A. ;

Chen, Herbert ;

Jensen, Robert T. ;

Kim, Michelle Kang ;

Klimstra, David S. ;

Kulke, Matthew H. ;

Liu, Eric H. ;

Metz, David C. ;

Phan, Alexandria T. ;

Sippel, Rebecca S. ;

Strosberg, Jonathan R. ;

Yao, James C. .

PANCREAS, 2013, 42 (04) :557-577

[25]

Lamarca A, 2017, NEUROENDOCRINOLOGY

[26] Surgical treatment of bronchial carcinoid tumors: A single-center experience [J].

Machuca, Tiago Noguchi ;

Guerreiro Cardoso, Paulo Francisco ;

Camargo, Spencer Marcantonio ;

Signori, Leonardo ;

Andrade, Cristiano Feijo ;

Schneider Moreira, Ana Luiza ;

Moreira, Jose da Silva ;

Felicetti, Jose Carlos ;

Camargo, Jose Jesus .

LUNG CANCER, 2010, 70 (02) :158-162

[27] Long-term results after resection of bronchial carcinoid tumour: evaluation of survival and prognostic factors [J].

Maurizi, Giulio ;

Ibrahim, Mohsen ;

Andreetti, Claudio ;

D'Andrilli, Antonio ;

Ciccone, Anna Maria ;

Pomes, Leda Marina ;

Menna, Cecilia ;

Pellegrini, Marianna ;

Venuta, Federico ;

Rendina, Erino Angelo .

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2014, 19 (02) :239-244

[28] Assessment of outcomes in typical and atypical carcinoids according to latest WHO classification [J].

Mezzetti, M ;

Raveglia, F ;

Panigalli, T ;

Giuliani, L ;

Lo Giudice, F ;

Meda, S ;

Conforti, S .

ANNALS OF THORACIC SURGERY, 2003, 76 (06) :1838-1842

[29] The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories [J].

Milione, Massimo ;

Maisonneuve, Patrick ;

Spada, Francesca ;

Pellegrinelli, Alessio ;

Spaggiari, Paola ;

Albarello, Luca ;

Pisa, Eleonora ;

Barberis, Massimo ;

Vanoli, Alessandro ;

Buzzoni, Roberto ;

Pusceddu, Sara ;

Concas, Laura ;

Sessa, Fausto ;

Solcia, Enrico ;

Capella, Carlo ;

Fazio, Nicola ;

La Rosa, Stefano .

NEUROENDOCRINOLOGY, 2017, 104 (01) :85-93

[30] Neuroendocrine bronchial and thymic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Oberg, K. ;

Hellman, P. ;

Ferolla, P. ;

Papotti, M. .

ANNALS OF ONCOLOGY, 2012, 23 :120-123

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