mRNA quantification of C-type natriuretic peptide in brain areas of rodents

被引：8

作者：

Stepan, H

Leitner, E

Siems, WE

Maul, B

Walther, T ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, Berlin, Germany

[2] Atugen AG, Berlin, Germany

[3] Res Inst Mol Pharmacol, Berlin, Germany

[4] Univ Leipzig, Dept Obstet & Gynecol, D-7010 Leipzig, Germany

来源：

PEPTIDES | 1999年 / 20卷 / 10期

关键词：

C-type natriuretic peptide (CNP); mouse brain; rat brain; RNase-protection assay;

D O I：

10.1016/S0196-9781(99)00129-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-type natriuretic peptide (CNP) is regarded as an endothelium-derived vasodilator and might therefore have an important role in controlling vascular tone and remodeling. Because CNP also is expressed in the brain, it is considered to be a neurotransmitter. The present study compares expression levels of CNP mRNA in distinct areas of the mouse brain with the expression pattern in the rat brain. A distinct expression of CNP was found in all investigated areas with the exception of the mouse striatum. In both rodents, high CNP expression was detected in the tegmentum. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：1243 / 1245

页数：3

共 11 条

[1] Effect of receptor blockers on brain natriuretic peptide and C-type natriuretic peptide caused anxiolytic state in rats [J].