Integration of denosumab therapy in the management of giant cell tumors of bone

被引：7

作者：

Miles, Daniel T. ^{[1
]}

Voskuil, Ryan T. ^{[2
,3
]}

Dale, Wood ^{[4
]}

Mayerson, Joel L. ^{[2
,3
]}

Scharschmidt, Thomas J. ^{[2
,3
]}

机构：

[1] Univ Tennessee, Coll Med, Dept Orthopaed Surg, Chattanooga, TN USA

[2] Ohio State Univ, James Canc Hosp, Div Musculoskeletal Oncol, Wexner Med Ctr,Nationwide Childrens Hosp, Columbus, OH 43210 USA

[3] Ohio State Univ, Solove Res Inst, Wexner Med Ctr, Nationwide Childrens Hosp, Columbus, OH 43210 USA

[4] Univ Mississippi, Sch Med, Dept Orthopaed & Rehabil, University, MS 38677 USA

来源：

JOURNAL OF ORTHOPAEDICS | 2020年 / 22卷

关键词：

Denosumab; RANKL; Giant cell tumor of the bone (GCTB); PHASE-II TRIAL; LOCAL RECURRENCE; ZOLEDRONIC ACID; BREAST-CANCER; OPEN-LABEL; PROSTATE-CANCER; GENE-EXPRESSION; CATHEPSIN-K; RANK LIGAND; OSTEOPROTEGERIN;

D O I：

10.1016/j.jor.2020.03.020

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

A review of the literature indicated denosumab is gaining favorability in the oncology community, particularly with increasing frequency in GCTB. Will denosumab be the breakthrough GCTB treatment? Here, we provide a pertinent case example, a review of the literature regarding the history and basic science behind the use of denosumab for GCTB, highlight the newest insights into the dosing and duration of treatment, and note advancements in the field.

引用

页码：38 / 47

页数：10

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