The MR-Base platform supports systematic causal inference across the human phenome

被引：5128

作者：

Hemani, Gibran ^{[1
]}

Zhengn, Jie ^{[1
]}

Elsworth, Benjamin ^{[1
]}

Wade, Kaitlin H. ^{[1
]}

Haberland, Valeriia ^{[1
]}

Baird, Denis ^{[1
]}

Laurin, Charles ^{[1
]}

Burgess, Stephen ^{[2
]}

Bowden, Jack ^{[1
]}

Langdon, Ryan ^{[1
]}

Tan, Vanessa Y. ^{[1
]}

Yarmolinsky, James ^{[1
]}

Shihab, Hashem A. ^{[1
]}

Timpson, Nicholas J. ^{[1
]}

Evans, David M. ^{[1
,3
]}

Relton, Caroline ^{[1
]}

Martin, Richard M. ^{[1
]}

Smith, George Davey ^{[1
]}

Gaunt, Tom R. ^{[1
]}

Haycock, Philip C. ^{[1
]}

机构：

[1] Univ Bristol, Bristol Med Sch, MRC, Populat Hlth Sci,Integrat Epidemiol Unit, Bristol, Avon, England

[2] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[3] Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld, Australia

来源：

ELIFE | 2018年 / 7卷

基金：

英国医学研究理事会; 英国惠康基金; 澳大利亚研究理事会;

关键词：

MENDELIAN RANDOMIZATION; GENOME-WIDE; GENETIC INFLUENCES; ASSOCIATION; RISK; GWAS; INSTRUMENTS; VARIANTS; DISEASE; DATABASE;

D O I：

10.7554/eLife.34408

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, 2SMR methods are evolving rapidly and GWAS results are often insufficiently curated, undermining efficient implementation of the approach. We therefore developed MR-Base (http://www.mrbase.org): a platform that integrates a curated database of complete GWAS results (no restrictions according to statistical significance) with an application programming interface, web app and R packages that automate 2SMR. The software includes several sensitivity analyses for assessing the impact of horizontal pleiotropy and other violations of assumptions. The database currently comprises 11 billion single nucleotide polymorphism-trait associations from 1673 GWAS and is updated on a regular basis. Integrating data with software ensures more rigorous application of hypothesis-driven analyses and allows millions of potential causal relationships to be efficiently evaluated in phenome-wide association studies.

引用

页数：29

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