The biosynthesis of murayaquinone, a rearranged polyketide

被引：14

作者：

Gould, SJ

Melville, CR

Chen, J

机构：

[1] Department of Chemistry, Oregon State University, Corvallis

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00226-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Incorporations of sodium [1,2-C-13(2)]acetate and sodium [1-C-13,O-18(2)]acetate confirmed that murayaquinone, produced by Streptomyces murayamaensis, is a polyketide. However, the labeling patterns revealed that a simple folding of the decaketide intermediate does not lead directly to the final phenanthrene skeleton. Instead a different phenanthrene is apparently formed that undergoes an oxidative cleavage, isomerization, and re-closure to a new phenanthrene skeleton. (C) 1997 Elsevier Science Ltd.

引用

页码：4561 / 4568

页数：8

共 27 条

[1]

BIRCH AJ, 1962, P CHEM SOC LONDON, P3

[2]

BIRCH AJ, 1958, CHEM SOC S, P16

[3] THE POTENTIAL ROLE OF FATTY-ACID INITIATION IN THE BIOSYNTHESIS OF THE FUNGAL AROMATIC POLYKETIDE AFLATOXIN B-1 [J].