Long-term remission of small cell lung cancer after reactivation of tuberculosis following immune-checkpoint blockade: A case report

被引：7
作者：
Sirgiovanni, Mattia [1 ,2 ]
Hinterleitner, Clemens [1 ,2 ]
Horger, Marius [3 ]
Atique, Naushad Bijoy [1 ,2 ]
Lauer, Ulrich M. [1 ,2 ]
Zender, Lars [1 ,2 ,4 ]
Hinterleitner, Martina [1 ,2 ]
机构：
[1] Univ Hosp Tuebingen, Dept Med Oncol & Pneumol, Tubingen, Germany
[2] Univ Tubingen, Cluster Excellence iFIT EXC Image Guided & Functi, Tubingen, Germany
[3] Univ Hosp Tuebingen, Dept Diagnost & Intervent Radiol, Tubingen, Germany
[4] German Canc Res Ctr, German Canc Res Consortium DKTK, Partner Site Tuebingen, Heidelberg, Germany
来源：
THORACIC CANCER | 2021年 / 12卷 / 05期
关键词：
immune-checkpoint inhibitors; lung cancer; PD-L1; tuberculosis;
D O I：
10.1111/1759-7714.13821
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune-checkpoint inhibitors (ICIs) provide a promising treatment option for advanced tumors including small cell lung cancer (SCLC). Nevertheless, in addition to immune-related adverse events (irAEs), an increased risk of infection including tuberculosis has been previously described. Here, we report a case of long-term remission of a patient with SCLC after reactivation of lung tuberculosis following ICI therapy. Our case illustrates the complexity of ICI-associated immune modulation in tuberculosis. Since new lesions in lung cancer patients are commonly associated with tumor progression, infections with mycobacterial tuberculosis may be underdiagnosed in lung cancer.
引用
收藏
页码：699 / 702
页数：4
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