Competition and compensation: Coupled to death in development and cancer

被引:60
作者
Abrams, JM [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA
关键词
D O I
10.1016/S0092-8674(02)00904-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "losers" in this process.
引用
收藏
页码:403 / 406
页数:4
相关论文
共 19 条
[1]   An emerging blueprint for apoptosis in Drosophila [J].
Abrams, JM .
TRENDS IN CELL BIOLOGY, 1999, 9 (11) :435-440
[2]   Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing [J].
Adachi-Yamada, T ;
Fujimura-Kamada, K ;
Nishida, Y ;
Matsumoto, K .
NATURE, 1999, 400 (6740) :166-169
[3]   Error and attack tolerance of complex networks [J].
Albert, R ;
Jeong, H ;
Barabási, AL .
NATURE, 2000, 406 (6794) :378-382
[4]   The molecular basis and potential role of survivin in cancer diagnosis and therapy [J].
Altieri, DC .
TRENDS IN MOLECULAR MEDICINE, 2001, 7 (12) :542-547
[5]  
Burke R, 1996, DEVELOPMENT, V122, P2261
[6]   Proliferation, cell cycle and apoptosis in cancer [J].
Evan, GI ;
Vousden, KH .
NATURE, 2001, 411 (6835) :342-348
[7]  
GARCIABELLIDO A, 1975, CIBA F SYMP, P161, DOI DOI 10.1002/9780470720110.CH8
[8]   A matter of life and death [J].
Green, DR ;
Evan, GI .
CANCER CELL, 2002, 1 (01) :19-30
[9]   The Drosophila Hox gene Deformed sculpts head morphology via direct regulation of the apoptosis activator reaper [J].
Lohmann, I ;
McGinnis, N ;
Bodmer, M ;
McGinnis, W .
CELL, 2002, 110 (04) :457-466
[10]   Destabilizing influences in apoptosis: sowing the seeds of IAP destruction [J].
Martin, SJ .
CELL, 2002, 109 (07) :793-796