Factors associated with late presentation for HIV care in a single Belgian reference center: 2006-2017

被引:33
作者
Darcis, Gilles [1 ]
Lambert, Iseult [1 ]
Sauvage, Anne-Sophie [1 ]
Frippiat, Frederic [1 ]
Meuris, Christelle [1 ]
Uurlings, Francoise [1 ]
Lecomte, Marianne [1 ]
Leonard, Philippe [1 ]
Giot, Jean-Baptiste [1 ]
Fombellida, Karine [1 ]
Vaira, Dolores [2 ]
Moutschen, Michel [1 ]
机构
[1] Liege Univ Hosp, Infect Dis Dept, Liege, Belgium
[2] Univ Liege, AIDS Reference Lab, Liege, Belgium
关键词
COMBINATION ANTIRETROVIRAL THERAPY; HETEROSEXUAL TRANSMISSION; MISSED OPPORTUNITIES; ACQUISITION; INFECTION; COUNTRIES;
D O I
10.1038/s41598-018-26852-0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Late presentation for HIV care is a major issue and the cause of higher morbidity, mortality and transmission. In this regard, we analyzed the characteristics of patients presenting for care at our center from January 2006 to July 2017 (n = 687). The majority of the studied population was of African origin (54.3%) with heterosexual women representing the main group (n = 292; 42.5%). 44% of the patients were late presenters (LP) (presenting for care with CD4T cells < 350/mm(3) or an AIDS defining event) and 24% were late presenters with advanced disease (LP-AD) (presenting for care with CD4T cells < 200/mm(3)or an AIDS defining event). A very high risk of being LP and LP-AD was associated with Sub-Saharan origin (OR 3.4 and 2.6 respectively). Otherfactors independently associated with LP or LP-AD were age (OR 1.3), male gender (OR 2.0 and 1.5 respectively) and heterosexual route of transmission (OR 2.4 and 2.3 respectively). A significant increase in HIV screening without forgetting those groups would contribute to earlier HIV diagnosis, a key element to end the HIV epidemic. To achieve this goal, addressing the specific hurdles to HIV testing in the migrant population is critical.
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页数:6
相关论文
共 32 条
[1]   Late Presentation for Human Immunodeficiency Virus Care in the United States and Canada [J].
Althoff, Keri N. ;
Gange, Stephen J. ;
Klein, Marina B. ;
Brooks, John T. ;
Hogg, Robert S. ;
Bosch, Ronald J. ;
Horberg, Michael A. ;
Saag, Michael S. ;
Kitahata, Mari M. ;
Justice, Amy C. ;
Gebo, Kelly A. ;
Eron, Joseph J. ;
Rourke, Sean B. ;
Gill, M. John ;
Rodriguez, Benigno ;
Sterling, Timothy R. ;
Calzavara, Liviana M. ;
Deeks, Steven G. ;
Martin, Jeffrey N. ;
Rachlis, Anita R. ;
Napravnik, Sonia ;
Jacobson, Lisa P. ;
Kirk, Gregory D. ;
Collier, Ann C. ;
Benson, Constance A. ;
Silverberg, Michael J. ;
Kushel, Margot ;
Goedert, James J. ;
McKaig, Rosemary G. ;
Van Rompaey, Stephen E. ;
Zhang, Jinbing ;
Moore, Richard D. .
CLINICAL INFECTIOUS DISEASES, 2010, 50 (11) :1512-1520
[2]   High levels of postmigration HIV acquisition within nine European countries [J].
Alvarez-del Arco, Debora ;
Fakoya, Ibidun ;
Thomadakis, Christos ;
Pantazis, Nikos ;
Touloumi, Giota ;
Gennotte, Anne-Francoise ;
Zuure, Freke ;
Barros, Henrique ;
Staehelin, Cornelia ;
Gopel, Siri ;
Boesecke, Christoph ;
Prestileo, Tullio ;
Volny-Anne, Alain ;
Burns, Fiona ;
del Amo, Julia .
AIDS, 2017, 31 (14) :1979-1988
[3]   HIV testing and counselling for migrant populations living in high-income countries: a systematic review [J].
Alvarez-del Arco, Debora ;
Monge, Susana ;
Azcoaga, Amaya ;
Rio, Isabel ;
Hernando, Victoria ;
Gonzalez, Cristina ;
Alejos, Belen ;
Maria Caro, Ana ;
Perez-Cachafeiro, Santiago ;
Ramirez-Rubio, Oriana ;
Bolumar, Francisco ;
Noori, Teymur ;
Del Amo, Julia .
EUROPEAN JOURNAL OF PUBLIC HEALTH, 2013, 23 (06) :1039-1045
[4]   Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection [J].
Ananworanich, Jintanat ;
Schuetz, Alexandra ;
Vandergeeten, Claire ;
Sereti, Irini ;
de Souza, Mark ;
Rerknimitr, Rungsun ;
Dewar, Robin ;
Marovich, Mary ;
van Griensven, Frits ;
Sekaly, Rafick ;
Pinyakorn, Suteeraporn ;
Phanuphak, Nittaya ;
Trichavaroj, Rapee ;
Rutvisuttinunt, Wiriya ;
Chomchey, Nitiya ;
Paris, Robert ;
Peel, Sheila ;
Valcour, Victor ;
Maldarelli, Frank ;
Chomont, Nicolas ;
Michael, Nelson ;
Phanuphak, Praphan ;
Kim, Jerome H. .
PLOS ONE, 2012, 7 (03)
[5]  
[Anonymous], LANCET HIV
[6]  
[Anonymous], EURO SURVEILL
[7]   Late presentation of HIV infection: a consensus definition [J].
Antinori, A. ;
Coenen, T. ;
Costagiola, D. ;
Dedes, N. ;
Ellefson, M. ;
Gatell, J. ;
Girardi, E. ;
Johnson, M. ;
Kirk, O. ;
Lundgren, J. ;
Mocroft, A. ;
Monforte, A. d'Arminio ;
Phillips, A. ;
Raben, D. ;
Rockstroh, J. K. ;
Sabin, C. ;
Sonnerborg, A. ;
de Wolf, F. .
HIV MEDICINE, 2011, 12 (01) :61-64
[8]   Immunologic strategies for HIV-1 remission and eradication [J].
Barouch, Dan H. ;
Deeks, Steven G. .
SCIENCE, 2014, 345 (6193) :169-174
[9]   Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV [J].
Castilla, J ;
del Romero, J ;
Hernando, V ;
Marincovich, B ;
García, S ;
Rodríguez, C .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 40 (01) :96-101
[10]   Diagnosing HIV Infection in Primary Care Settings: Missed Opportunities [J].
Chin, Tammy ;
Hicks, Charles ;
Samsa, Gregory ;
McKellar, Mehri .
AIDS PATIENT CARE AND STDS, 2013, 27 (07) :392-397