Pituitary adenomas treated by microsurgery with or without Gamma Knife surgery: Experience in 122 cases

被引:41
作者
Inoue, HK
Kohga, H
Hirato, M
Sasaki, T
Ishihara, J
Shibazaki, T
Ohye, C
Andou, Y
机构
[1] Gunma Univ, Sch Med, Dept Neurosurg, Gunma, Japan
[2] Hidaka Hosp, Gamma Knife Ctr, Gunma, Japan
关键词
pituitary adenoma; Gamma Knife surgery; microsurgery; capsular removal; macroadenoma; tumor control; endocrinopathy;
D O I
10.1159/000056448
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The clinical outcome of 122 patients with pituitary adenomas treated by microsurgery and/or Gamma Knife radiosurgery (GKRS) was analyzed to evaluate patient selection criteria and the role of GKRS. Sixty-six resections were performed in 59 patients. All tumors were macroadenomas, except for 5 ACTH-producing adenomas. Twenty-four of the 31 hypersecreting adenomas showed normal serum hormone values after treatment. Postoperative complications were rhinorrhea, cranial nerve palsies, and a small thalamic infarct. GKRS was performed on 18 of the operated patients because of residual tumors, mostly in the cavernous sinus. Thirty-five of the 63 patients treated by GKRS were followed for more than 2 years. All adenomas except 2 were stable or had decreased in size. Eleven of 17 functioning adenomas showed normal serum hormone values after treatment. It is concluded that tumors that compress the optic pathway should be removed and that residual tumors in the cavernous sinus are good indications for radiosurgery. Copyright (C) 1999 S. Karger AG, Basel.
引用
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页码:125 / 131
页数:7
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