Cognitive neuroscience - The molecules of forgetfulness

被引：9
作者：
Silva, AJ
Josselyn, SA
机构：
[1] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Inst Brain Res, Los Angeles, CA 90095 USA
来源：
NATURE | 2002年 / 418卷 / 6901期
关键词：
D O I：
10.1038/418929a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Not everything that we learn is useful, so the brain needs a mechanism to prevent itself being burdened by unhelpful details. The molecular details of this mechanism are now being uncovered.
引用
收藏
页码：929 / 930
页数：3
相关论文
共 13 条
[1]   Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP [J].
Blitzer, RD ;
Conner, JH ;
Brown, GP ;
Wong, T ;
Shenolikar, S ;
Iyengar, R ;
Landau, EM .
SCIENCE, 1998, 280 (5371) :1940-1943
[2]   PROTEIN-SYNTHESIS AND MEMORY - A REVIEW [J].
DAVIS, HP ;
SQUIRE, LR .
PSYCHOLOGICAL BULLETIN, 1984, 96 (03) :518-559
[3]  
Ebbinghaus H., 1885, BER GED CHTNIS UNTER
[4]   Protein phosphatase 1 is a molecular constraint on learning and memory [J].
Genoux, D ;
Haditsch, U ;
Knobloch, M ;
Michalon, A ;
Storm, D ;
Mansuy, IM .
NATURE, 2002, 418 (6901) :970-975
[5]   Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala [J].
Josselyn, SA ;
Shi, CJ ;
Carlezon, WA ;
Neve, RL ;
Nestler, EJ ;
Davis, M .
JOURNAL OF NEUROSCIENCE, 2001, 21 (07) :2404-2412
[6]   Spaced training induces normal long-term memory in CREB mutant mice [J].
Kogan, JH ;
Frankland, PW ;
Blendy, JA ;
Coblentz, J ;
Marowitz, Z ;
Schutz, G ;
Silva, AJ .
CURRENT BIOLOGY, 1997, 7 (01) :1-11
[7]   The molecular basis of CaMKII function in synaptic and behavioural memory [J].
Lisman, J ;
Schulman, H ;
Cline, H .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (03) :175-190
[8]   Control of memory formation through regulated expression of a CaMKII transgene [J].
Mayford, M ;
Bach, ME ;
Huang, YY ;
Wang, L ;
Hawkins, RD ;
Kandel, ER .
SCIENCE, 1996, 274 (5293) :1678-1683
[9]  
MAYFORD M, 1997, CURR BIOL, V7, P580
[10]   Transcriptional regulation by the phosphorylation-dependent factor CREB [J].
Mayr, B ;
Montminy, M .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (08) :599-609
12