Fragile X Mental Retardation Protein and the Ribosome

被引：2

作者：

Harigaya, Yuriko ^{[1
,2
]}

Parker, Roy ^{[1
,2
]}

机构：

[1] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80303 USA

[2] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80303 USA

来源：

MOLECULAR CELL | 2014年 / 54卷 / 03期

关键词：

TRANSLATION; FMRP;

D O I：

10.1016/j.molcel.2014.04.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Molecular Cell, Chen et al. (2014) provide evidence that FMRP represses translation by binding the ribosome, suggesting a novel form of translational control.

引用

页码：330 / 332

页数：4

共 10 条

[1] Stm1 modulates translation after 80S formation in Saccharomyces cerevisiae [J].

Balagopal, Vidya ;

Parker, Roy .

RNA, 2011, 17 (05) :835-842

[2] Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome [J].

Brown, V ;

Jin, P ;

Ceman, S ;

Darnell, JC ;

O'Donnell, WT ;

Tenenbaum, SA ;

Jin, XK ;

Feng, Y ;

Wilkinson, KD ;

Keene, JD ;

Darnell, RB ;

Warren, ST .

CELL, 2001, 107 (04) :477-487

[3] Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome [J].

Chen, Eileen ;

Sharma, Manjuli R. ;

Shi, Xinying ;

Agrawal, Rajendra K. ;

Joseph, Simpson .

MOLECULAR CELL, 2014, 54 (03) :407-417

[4] FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism [J].

Darnell, Jennifer C. ;

Van Driesche, Sarah J. ;

Zhang, Chaolin ;

Hung, Ka Ying Sharon ;

Mele, Aldo ;

Fraser, Claire E. ;

Stone, Elizabeth F. ;

Chen, Cynthia ;

Fak, John J. ;

Chi, Sung Wook ;

Licatalosi, Donny D. ;

Richter, Joel D. ;

Darnell, Robert B. .

CELL, 2011, 146 (02) :247-261

[5] A conserved PUF-Ago-eEF1A complex attenuates translation elongation [J].

Friend, Kyle ;

Campbell, Zachary T. ;

Cooke, Amy ;

Kroll-Conner, Peggy ;

Wickens, Marvin P. ;

Kimble, Judith .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (02) :176-183

[6] elF5A Promotes Translation of Polyproline Motifs [J].

Gutierrez, Erik ;

Shin, Byung-Sik ;

Woolstenhulme, Christopher J. ;

Kim, Joo-Ran ;

Saini, Preeti ;

Buskirk, Allen R. ;

Dever, Thomas E. .

MOLECULAR CELL, 2013, 51 (01) :35-45

[7] The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP [J].

Napoli, Ilaria ;

Mercaldo, Valentina ;

Boyl, Pietro Pilo ;

Eleuteri, Boris ;

Zalfa, Francesca ;

De Rubeis, Silvia ;

Di Marino, Daniele ;

Mohr, Evita ;

Massimi, Marzia ;

Falconi, Mattia ;

Witke, Walter ;

Costa-Mattioli, Mauro ;

Sonenberg, Nahum ;

Achsel, Tilmann ;

Bagni, Claudia .

CELL, 2008, 134 (06) :1042-1054

[8] The State of Synapses in Fragile X Syndrome [J].

Pfeiffer, Brad E. ;

Huber, Kimberly M. .

NEUROSCIENTIST, 2009, 15 (05) :549-567

[9] FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control [J].

Sudhakaran, Indulekha P. ;

Hillebrand, Jens ;

Dervan, Adrian ;

Das, Sudeshna ;

Holohan, Eimear E. ;

Huelsmeier, Joern ;

Sarov, Mihail ;

Parker, Roy ;

VijayRaghavan, K. ;

Ramaswami, Mani .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (01) :E99-E108

[10] Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology [J].

Udagawa, Tsuyoshi ;

Farny, Natalie G. ;

Jakovcevski, Mira ;

Kaphzan, Hanoch ;

Alarcon, Juan Marcos ;

Anilkumar, Shobha ;

Ivshina, Maria ;

Hurt, Jessica A. ;

Nagaoka, Kentaro ;

Nalavadi, Vijayalaxmi C. ;

Lorenz, Lori J. ;

Bassell, Gary J. ;

Akbarian, Schahram ;

Chattarji, Sumantra ;

Klann, Eric ;

Richter, Joel D. .

NATURE MEDICINE, 2013, 19 (11) :1473-+

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