A mild and efficient method for large scale synthesis of 3-aminocoumarins and its further application for the preparation of 4-bromo-3-aminocoumarins

被引：16
作者：
Das, Deb K. [1 ]
Sarkar, Satavisha [1 ]
Khan, Musawwer [3 ]
Belal, Md. [1 ]
Khan, Abu T. [1 ,2 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
[2] Aliah Univ, Kolkata 700091, W Bengal, India
[3] Aligarh Muslim Univ, Dept Chem, Aligarh 202002, Uttar Pradesh, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 35期
关键词：
3-Acetamidocoumarins; 3-Aminocoumarins; Salicylaldehydes; N-Acetylglycine; Sulfuric acid; BIOLOGICAL EVALUATION; BROMODIMETHYLSULFONIUM BROMIDE; DERIVATIVES; NOVOBIOCIN; INHIBITORS; COUMARINS; TRANSFORMATIONS; BROMINATION; PREVENTION; PYRROLES;
D O I：
10.1016/j.tetlet.2014.07.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide variety of 3-aminocoumarins have been synthesized in large scale from the corresponding 3-acetamidocoumarins by regioselective cleavage of carbon-nitrogen bond using 70% sulfuric acid under reflux conditions. The synthesized 3-aminocoumarins were further brominated regioselectively at the 4-position of 3-aminocoumarin using BDMS as brominating agent. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4869 / 4874
页数：6
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