The role of epidermal growth factor receptor in prognosis and treatment of gastric cancer

被引：22
作者：
Hong, Liu [1 ,2 ]
Han, Yu [2 ]
Brain, Lubi [3 ]
机构：
[1] Fourth Mil Med Univ, Xijing Hosp, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi Provinc, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol, Xian 710032, Shaanxi Provinc, Peoples R China
[3] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21231 USA
来源：
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2014年 / 8卷 / 01期
关键词：
epidermal growth factor receptor; gastric cancer; prognosis; target therapy; PHASE-II TRIAL; ANTITUMOR-ACTIVITY; TYROSINE KINASE; EGFR-FAMILY; CETUXIMAB; COMBINATION; INHIBITOR; LAPATINIB; EXPRESSION; THERAPY;
D O I：
10.1586/17474124.2014.844648
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Despite tremendous efforts to reduce deaths due to gastric cancer, it represents the second leading cause of cancer-related deaths worldwide. EGF receptor (EGFR) plays important roles in gastric carcinogenesis by regulation of cell cycle, angiogenesis and apoptosis. This review evaluates the functions, mechanisms and clinical uses of EGFR in gastric cancer. Although EGFR targeted single therapy shows limited effect, the combination of EGFR targeted agents with traditional chemotherapy regimens may bring about important progress in cancer therapy. More clinical trials should be performed to clarify both the prognostic and therapeutic value of EGFR in gastric cancer.
引用
收藏
页码：111 / 117
页数：7
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