A metabolic view on menopause and ageing

被引：211

作者：

Auro, Kirsi ^{[1
,2
,3
,4
]}

Joensuu, Anni ^{[1
,2
]}

Fischer, Krista ^{[5
]}

Kettunen, Johannes ^{[1
,2
,6
]}

Salo, Perttu ^{[1
,2
]}

Mattsson, Hannele ^{[1
,2
]}

Niironen, Marjo ^{[1
]}

Kaprio, Jaakko ^{[2
,7
,8
]}

Eriksson, Johan G. ^{[9
,10
,11
,12
,13
]}

Lehtimaki, Terho ^{[14
]}

Raitakari, Olli ^{[15
]}

Jula, Antti ^{[9
]}

Tiitinen, Aila ^{[3
,4
]}

Jauhiainen, Matti ^{[1
,2
]}

Soininen, Pasi ^{[6
,16
]}

Kangas, Antti J. ^{[6
,16
]}

Kahonen, Mika ^{[17
,18
]}

Havulinna, Aki S. ^{[9
]}

Ala-Korpela, Mika ^{[6
,16
,19
,20
,21
]}

Salomaa, Veikko ^{[9
]}

Metspalu, Andres ^{[5
]}

Perola, Markus ^{[1
,2
,5
]}

机构：

[1] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Publ Hlth Genom Unit, Biomedicum 1, Helsinki 00290, Finland

[2] Univ Helsinki, Inst Mol Med FIMM, Biomedicum 2, FIN-00290 Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00290 Helsinki, Finland

[4] Univ Helsinki, FIN-00290 Helsinki, Finland

[5] Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia

[6] Univ Oulu, Inst Hlth Sci, FIN-90570 Oulu, Finland

[7] Univ Helsinki, Hjelt Inst, Dept Publ Hlth, FIN-00014 Helsinki, Finland

[8] Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, Helsinki 00300, Finland

[9] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki 00300, Finland

[10] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki 00029, Finland

[11] Vasa Cent Hosp, Vaasa 65130, Finland

[12] Helsingfors Univ, Folkhalsan Res Ctr, Helsinki 00014, Finland

[13] Univ Helsinki, Cent Hosp, Unit Gen Practice, FIN-00290 Helsinki, Finland

[14] Tampere Univ, Univ Tampere, Sch Med, Dept Clin Chem,Fimlab Labs, Tampere 33014, Finland

[15] Univ Turku, Turku Univ Hosp, Res Ctr Appl & Prevent Cardiovasc Med, Dept Clin Physiol & Nucl Med, Turku 20521, Finland

[16] Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio 70211, Finland

[17] Tampere Univ, Tampere Univ Hosp, Dept Clin Physiol, Tampere 33014, Finland

[18] Tampere Univ, Univ Tampere, Sch Med, Tampere 33014, Finland

[19] Oulu Univ Hosp, Oulu 90220, Finland

[20] Univ Bristol, Sch Social & Community Med, Bristol BS8 1TH, Avon, England

[21] Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol BS8 1TH, Avon, England

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

芬兰科学院;

关键词：

CORONARY-HEART-DISEASE; POLYUNSATURATED FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; RISK-FACTORS; OMEGA-3-FATTY-ACID INTAKE; ENDOTHELIAL DYSFUNCTION; GENDER-DIFFERENCES; INSULIN-SECRETION;

D O I：

10.1038/ncomms5708

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065 individuals of Northern European ancestry. Age-specific metabolic fingerprints differ significantly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal transition is observed. In meta-analysis of 10,083 women, menopause status associates with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and atherogenic lipoproteins. Among 3,204 women aged 40-55 years, menopause status associates additionally with glycine and total, monounsaturated, and omega-7 and -9 fatty acids. Our findings suggest that, in addition to lipid alterations, menopause may contribute to future metabolic and cardiovascular risk via influencing amino-acid concentrations, adding to the growing evidence of the importance of amino acids in metabolic disease progression. These observations shed light on the metabolic consequences of ageing, gender and menopause at the population level.

引用

页数：11

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