Cardiovascular Risk Factors and Atherosclerosis in Young Women Atherosclerosis Risk Factors in Female Youngsters (ARFY Study)

被引:76
作者
Knoflach, Michael [1 ]
Kiechl, Stefan [1 ]
Penz, Daniela [1 ]
Zangerle, Alexandra [1 ]
Schmidauer, Christoph [1 ]
Rossmann, Andrea [2 ]
Shingh, Mahavir [6 ]
Spallek, Ralf [7 ]
Griesmacher, Andrea [3 ]
Bernhard, David [4 ]
Robatscher, Peter [5 ]
Buchberger, Waltraud [8 ]
Draxl, Walter [8 ]
Willeit, Johann [1 ]
Wick, Georg [2 ]
机构
[1] Innsbruck Med Univ, Dept Clin Neurol, A-6020 Innsbruck, Austria
[2] Innsbruck Med Univ, Lab Autoimmun, Div Expt Pathophysiol & Immunol, Bioctr, A-6020 Innsbruck, Austria
[3] Innsbruck Med Univ, Cent Inst Med & Chem Lab Diagnost, A-6020 Innsbruck, Austria
[4] Innsbruck Med Univ, Dept Cardiac Surg, A-6020 Innsbruck, Austria
[5] Innsbruck Med Univ, Clin Dept Prosthet Dent, A-6020 Innsbruck, Austria
[6] Helmholtz Ctr Infect Res, Braunschweig, Germany
[7] LIONEX Diagnost & Therapeut GmbH, Braunschweig, Germany
[8] Tyrol State Hosp Ltd, Educ Ctr W Allied Hlth Profess, Innsbruck, Austria
关键词
atherosclerosis; female; human; risk factors; young adult; INTIMA-MEDIA THICKNESS; C-REACTIVE PROTEIN; SERUM ANTIBODIES; CHILDHOOD; ADULTHOOD; ASSOCIATION; LIPOPROTEIN; PREDICTION; LESIONS; STROKE;
D O I
10.1161/STROKEAHA.108.525675
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-Little research has been conducted into risk factors of atherosclerosis development in young women. Methods-This cross-sectional study enrolled 205 18- to 22-year-old female students from the Educational Centre for Allied Health Professions. A broad array of risk conditions and lifestyle behaviors was carefully assessed. Intima media thickness (IMT) was used as a well-established surrogate for atherosclerosis and a predictor of vascular risk. High IMT was defined as levels exceeding the 90th percentile in the common and/or internal carotid arteries. Results-In multivariable logistic regression analysis, systolic blood pressure, family history for hypertension, lipoprotein(a), homocysteine, T-cell immune reaction against human heat shock protein 60, and exposure to environmental tobacco smoke and exhaust gases emerged as independent predictors of high IMT. Obesity, metabolic syndrome, and classical risk factors other than high blood pressure were rare and unrelated to IMT. Findings were similar once focusing on IMT as a continuous variable. Conclusion-In female youngsters displaying initiating stages of vascular pathology, blood pressure level and numerous nontraditional risk conditions showed a significant relation to high IMT. Our study indicates that (auto)immune processes, high lipoprotein(a), and environmental exposure to tobacco smoke and traffic exhaust may play a role in early atherogenesis. (Stroke. 2009;40:1063-1069.)
引用
收藏
页码:1063 / 1069
页数:7
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