Synthesis and characterization of a series of novel amino β-cyclodextrin-conjugated poly(ε-lysine) derivatives

Soluble poly(epsilon-lysine)s bearing beta-cyclodextrin (beta-CD) moieties were prepared by three amino beta-CD derivatives and N-succinylated poly(epsilon-lysine), in which the poly(e-lysine) and amino beta-CD derivatives were bonded covalently to the end carboxyl groups of succinic acid by peptide bonds. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI) and N-hydroxysuccinimide (NHS) were chosen to assist the reaction. The three poly(epsilon-lysine) derivatives were characterized by H-1 nuclear magnetic resonance (H-1 NMR) and Fourier transform infrared (FT-IR). The synthesis process is simple, feasible and has strong practicability. The target polymers can serve as new polymer biomaterial for use in the biotechnology area.