Advances in Gold Nanoparticle-Based Combined Cancer Therapy

被引:71
作者
Bromma, Kyle [1 ]
Chithrani, Devika B. [1 ,2 ,3 ,4 ]
机构
[1] Univ Victoria, Dept Phys & Astron, Victoria, BC V8P 5C2, Canada
[2] Med Phys, British Columbia Canc, Victoria, BC V8R 6V5, Canada
[3] Univ Victoria, Ctr Adv Mat & Related Technol CAMTEC, Victoria, BC V8P 5C2, Canada
[4] Univ Victoria, Ctr Biomed Res, Victoria, BC V8P 5C2, Canada
基金
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词
gold nanoparticles; radiation; chemotherapy; radiosensitizer; drug delivery system; chemoradiotherapy; SINGLE-PARTICLE TRACKING; WALLED CARBON NANOTUBES; IN-VIVO; RADIATION-THERAPY; COLLOIDAL GOLD; DRUG-DELIVERY; CELL-CYCLE; ENHANCED RADIOTHERAPY; INTRACELLULAR UPTAKE; PANCREATIC-CANCER;
D O I
10.3390/nano10091671
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
According to the global cancer observatory (GLOBOCAN), there are approximately 18 million new cancer cases per year worldwide. Cancer therapies are largely limited to surgery, radiotherapy, and chemotherapy. In radiotherapy and chemotherapy, the maximum tolerated dose is presently being used to treat cancer patients. The integrated development of innovative nanoparticle (NP) based approaches will be a key to address one of the main issues in both radiotherapy and chemotherapy: normal tissue toxicity. Among other inorganic NP systems, gold nanoparticle (GNP) based systems offer the means to further improve chemotherapy through controlled delivery of chemotherapeutics, while local radiotherapy dose can be enhanced by targeting the GNPs to the tumor. There have been over 20 nanotechnology-based therapeutic products approved for clinical use in the past two decades. Hence, the goal of this review is to understand what we have achieved so far and what else we can do to accelerate clinical use of GNP-based therapeutic platforms to minimize normal tissue toxicity while increasing the efficacy of the treatment. Nanomedicine will revolutionize future cancer treatment options and our ultimate goal should be to develop treatments that have minimum side effects, for improving the quality of life of all cancer patients.
引用
收藏
页码:1 / 25
页数:25
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