H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation

被引：53

作者：

Sluss, Hayla K. ^{[1
]}

Davis, Roger J.

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Cell Biol, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Mol Sci Program, Worcester, MA 01605 USA

[3] Howard Hughes Med Inst, Worcester, MA 01605 USA

来源：

MOLECULAR CELL | 2006年 / 23卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2006.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanism of apoptotic signaling by JNK is incompletely understood. In the July 7 issue of Molecular Cell, Lu et al. (2006) report that JNK phosphorylation of H2AX at a noncanonical site is required for caspase-induced DNA fragmentation.

引用

页码：152 / 153

页数：2

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