Human congenital long QT syndrome: more than previously thought?

被引：8

作者：

Attali, B ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 06期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/S0165-6147(02)02029-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mutations in KCNQ1 and KCNE1,the alpha- and beta-subunits of the I-KS K+ channel, produce the cardiac long QT (LQT) syndrome. These subunits are expressed in heart and inner ear, but also in epithelial tissues such as kidney or intestine where their functional roles have remained elusive. Recent work has shown that KCNE1-deficient mice display chronic hypokalemia and hyperaldosteronism. These results have significant implications for human congenital LQT syndromes because hypokalemia increases the risk of ventricular arrhythmia and cardiac sudden death.

引用

页码：249 / 251

页数：3

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