Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres

被引：20

作者：

Stankovic, Dalibor M. ^{[1
]}

Jovic, Milica ^{[2
]}

Ognjanovic, Milos ^{[1
]}

Lesch, Andreas ^{[3
]}

Fabian, Martin ^{[4
]}

Girault, Hubert H. ^{[2
]}

Antic, Bratislav ^{[1
]}

机构：

[1] Univ Belgrade, Vinca Inst Nucl Sci, POB 522, Belgrade 11001, Serbia

[2] EPFL Valais Wallis, Lab Phys & Analyt Electrochem LEPA, Rue Ind 17, CH-1951 Sion, Switzerland

[3] Univ Bologna, Dept Ind Chem Toso Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy

[4] Inst Geotech SAS, Watsonova 45, Kosice 04001, Slovakia

来源：

MICROCHIMICA ACTA | 2019年 / 186卷 / 08期

关键词：

Levodopa; Electrochemical sensor; Manganese dioxide; Cyclic voltammetry; Amperometry; Point-of-care; ASCORBIC-ACID; ELECTROCHEMICAL DETERMINATION; GLUCOSE-OXIDASE; PASTE ELECTRODE; GRAPHENE; TITANIUM; SENSOR; PERFORMANCES; BIOSENSOR; LEVODOPA;

D O I：

10.1007/s00604-019-3644-x

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An electrochemical sensor is described for the determination of L-dopa (levodopa; 3,4-dihydroxyphenylalanine). An inkjet-printed carbon nanotube (IJPCNT) electrode was modified with manganese dioxide microspheres by drop-casting. They coating was characterized by field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and X-ray powder diffraction. The sensor, best operated at a working voltage of 0.3V, has a linear response in the 0.1 to 10 mu ML-dopa concentration range, a 54nM detection limit, excellent reproducibility, repeatability and selectivity. The amperometric approach was applied to the determination of L-dopa in spiked biological fluids and displayed satisfactory accuracy and precision.

引用

页数：8

共 34 条

[1] A disposable electrochemical biosensor for L-DOPA determination in undiluted human serum [J].

Brunetti, Barbara ;

Valdes-Ramirez, Gabriela ;

Litvan, Irene ;

Wang, Joseph .

ELECTROCHEMISTRY COMMUNICATIONS, 2014, 48 :28-31

[2] Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED [J].

Bugamelli, F. ;

Marcheselli, C. ;

Barba, E. ;

Raggi, M. A. .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 54 (03) :562-567

[3] Amperometric ascorbic acid sensor based on doped ferrites nanoparticles modified glassy carbon paste electrode [J].

Dimitrijevic, Teodora ;

Vulic, Predrag ;

Manojlovic, Dragan ;

Nikolic, Aleksandar S. ;

Stankovic, Dalibor M. .

ANALYTICAL BIOCHEMISTRY, 2016, 504 :20-26

[4] Determination of L-dopa and L-dopamine in aqueous solutions using in-loop SPME coupled with LC [J].

Djozan, D ;

Amir-Zehni, M .

CHROMATOGRAPHIA, 2005, 62 (3-4) :127-132

[5] Electrochemical Study of Hydrogen Peroxide Detection on MnO2 Micromaterials [J].

Feng, Lili ;

Wang, Rui ;

Shi, Yulu ;

Wang, Hongbin ;

Yang, Jianhua ;

Zhu, Jiang ;

Chen, Yan ;

Yuan, Na .

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE, 2016, 11 (07) :5962-5972

[6] Development of a sensor for L-Dopa based on Co(DMG)2ClPy/multi-walled carbon nanotubes composite immobilized on basal plane pyrolytic graphite electrode [J].

Figueiredo Leite, Fernando Roberto ;

Maroneze, Camila Marchetti ;

de Oliveira, Adriano Bof ;

Pio dos Santos, Wallans Torres ;

Damos, Flavio Santos ;

Silva Luz, Rita de Cassia .

BIOELECTROCHEMISTRY, 2012, 86 :22-29

[7] Glucose microbiosensor based on MnO2 and glucose oxidase modified carbon fiber microelectrode [J].

Hocevar, SB ;

Ogorevc, B ;

Schachl, K ;

Kalcher, K .

ELECTROANALYSIS, 2004, 16 (20) :1711-1716

[8] Simple and rapid detection of L-dopa based on in situ formation of polylevodopa nanoparticles [J].

Hormozi-Nezhad, M. Reza ;

Moslehipour, Ahmad ;

Bigdeli, Arafeh .

SENSORS AND ACTUATORS B-CHEMICAL, 2017, 243 :715-720

[9]

Jayakumar C, 2013, ANAL BIOANAL ELECTRO, V5, P193

[10] Large-scale layer-by-layer inkjet printing of flexible iridium-oxide based pH sensors [J].

Jovic, Milica ;

Hidalgo-Acosta, Jonnathan C. ;

Lesch, Andreas ;

Bassetto, Victor Costa ;

Smirnov, Evgeny ;

Cortes-Salazar, Fernando ;

Girault, Hubert H. .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2018, 819 :384-390

← 1 2 3 4 →