Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

被引：2
作者：
Rei Yan, Sun Liu [1 ]
Wakasuqui, Felipe [1 ]
Du, Xiaochen [2 ]
Groves, Matthew R. [2 ]
Wrenger, Carsten [1 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci ICB, Dept Parasitol, Unit Drug Discovery, Sao Paulo, Brazil
[2] Univ Groningen, Groningen Res Inst Pharm, Dept Drug Design, Struct Biol Drug Design, Groningen, Netherlands
来源：
FRONTIERS IN CHEMISTRY | 2021年 / 9卷
基金：
巴西圣保罗研究基金会;
关键词：
Lipoic acid; malaria; protein lipoylation; Plasmodium; S; aureus; Lipoic acid (LA); lipoylation;
D O I：
10.3389/fchem.2021.742175
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as Plasmodium sp. and Staphylococcus aureus, including pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in Plasmodium sp. and Staphylococcus aureus, by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.
引用
收藏
页数：7
相关论文
共 56 条
  • [1] Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum
    Afanador, Gustavo A.
    Matthews, Krista A.
    Bartee, David
    Gisselberg, Jolyn E.
    Walters, Maroya S.
    Meyers, Caren L. Freel
    Prigge, Sean T.
    [J]. MOLECULAR MICROBIOLOGY, 2014, 94 (01) : 156 - 171
  • [2] Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum
    Allary, Marina
    Lu, Jeff Zhiqiang
    Zhu, Liqun
    Prigge, Sean T.
    [J]. MOLECULAR MICROBIOLOGY, 2007, 63 (05) : 1331 - 1344
  • [3] Lipid Lowering Effect of Antioxidant Alpha-Lipoic Acid in Experimental Atherosclerosis
    Amom, Zulkhairi
    Zakaria, Zaiton
    Mohamed, Jamaluddin
    Azlan, Azrina
    Bahari, Hasnah
    Baharuldin, Mohd Taufik Hidayat
    Moklas, Mohd Aris
    Osman, Khairul
    Asmawi, Zanariyah
    Hassan, Mohd Kamal Nik
    [J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2008, 43 (02) : 88 - 94
  • [4] Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes
    Biddau, Marco
    Kumar, T. R. Santha
    Henrich, Philipp
    Laine, Larissa M.
    Blackburn, Gavin J.
    Chokkathukalam, Achuthanunni
    Li, Tao
    Sim, Kim Lee
    King, Lewis
    Hoffman, Stephen L.
    Barrett, Michael P.
    Coombs, Graham H.
    McFadden, Geoffrey I.
    Fidock, David A.
    Mueller, Sylke
    Sheiner, Lilach
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2021, 51 (06) : 441 - 453
  • [5] Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes
    Cao, Xinyun
    Zhu, Lei
    Song, Xuejiao
    Hu, Zhe
    Cronan, John E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (30) : E7063 - E7072
  • [6] Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle
    Cao, Xinyun
    Hong, Yaoqin
    Zhu, Lei
    Hu, Yuanyuan
    Cronan, John E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (04) : 647 - 655
  • [7] Sulfur Mobilization for Fe-S Cluster Assembly by the Essential SUF Pathway in the Plasmodium falciparum Apicoplast and Its Inhibition
    Charan, Manish
    Singh, Nidhi
    Kumar, Bijay
    Srivastava, Kumkum
    Siddiqi, Mohammad Imran
    Habib, Saman
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (06) : 3389 - 3398
  • [8] Lipoic Acid Synthesis: A New Family of Octanoyltransferases Generally Annotated as Lipoate Protein Ligases
    Christensen, Quin H.
    Cronan, John E.
    [J]. BIOCHEMISTRY, 2010, 49 (46) : 10024 - 10036
  • [9] Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast
    Crawford, Michael J.
    Thomsen-Zieger, Nadine
    Ray, Manisha
    Schachtner, Joachim
    Roos, David S.
    Seeber, Frank
    [J]. EMBO JOURNAL, 2006, 25 (13) : 3214 - 3222
  • [10] Mitochondrial lipoic acid scavenging is essential for Plasmodium berghei liver stage development
    Deschermeier, Christina
    Hecht, Leonie-Sophie
    Bach, Frauke
    Ruetzel, Katharina
    Stanway, Rebecca R.
    Nagel, Andreas
    Seeber, Frank
    Heussler, Volker T.
    [J]. CELLULAR MICROBIOLOGY, 2012, 14 (03) : 416 - 430
123456