Bioactive Antioxidant Compounds from Chestnut Peels through Semi-Industrial Subcritical Water Extraction

被引：32
作者：
Cravotto, Christian [1 ,2 ]
Grillo, Giorgio [2 ]
Binello, Arianna [2 ]
Gallina, Lorenzo [2 ]
Olivares-Vicente, Marilo [3 ]
Herranz-Lopez, Maria [3 ]
Micol, Vicente [3 ,4 ]
Barrajon-Catalan, Enrique [3 ]
Cravotto, Giancarlo [2 ]
机构：
[1] Avignon Univ, GREEN Extract Team, INRAE, UMR 408, F-84000 Avignon, France
[2] Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy
[3] Univ Miguel Hernandez UMH, Inst Invest Desarrollo & Innovac Biotecnol Sanita, Elche 03202, Spain
[4] Carlos III Hlth Inst, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 05期
关键词：
subcritical water extraction; chestnut peels; polyphenols; tannins; semi-industrial scale; bioactivity; adipocytes; ultra-nano filtration; CASTANEA-SATIVA; TANNINS; VALORIZATION; POLYPHENOLS; SOLVENT; WASTES; SHELLS;
D O I：
10.3390/antiox11050988
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chestnut peels are a poorly characterized, underexploited by-product of the agri-food industry. This raw material is rich in bioactive compounds, primarily polyphenols and tannins, that can be extracted using different green technologies. Scaling up the process for industrial production is a fundamental step for the valorization of the extract. In this study, subcritical water extraction was investigated to maximize the extraction yield and polyphenol content. Lab-scale procedures have been scaled up to the semi-industrial level as well as the downstream processes, namely, concentration and spray drying. The extract antioxidant capacity was tested using in vitro and cellular assays as well as a preliminary evaluation of its antiadipogenic activity. The temperature, extraction time, and water/solid ratio were optimized, and the extract obtained under these conditions displayed a strong antioxidant capacity both in in vitro and cellular tests. Encouraging data on the adipocyte model showed the influence of chestnut extracts on adipocyte maturation and the consequent potential antiadipogenic activity. Chestnut peel extracts characterized by strong antioxidant power and potential antiadipogenic activity were efficiently obtained by removing organic solvents. These results prompted further studies on fraction enrichment by ultra- and nanofiltration. The semi-industrial eco-friendly extraction process and downstream benefits reported here may open the door to production and commercialization.
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页数：23
相关论文
共 55 条
[31]   Study of the DPPH•-scavenging activity: Development of a free software for the correct interpretation of data [J].
Locatelli, Monica ;
Gindro, Roberto ;
Travaglia, Fabiano ;
Coisson, Jean-Daniel ;
Rinaldi, Maurizio ;
Arlorio, Marco .
FOOD CHEMISTRY, 2009, 114 (03) :889-897
[32]   Thermal stability of catechin and epicatechin upon disaccharides addition [J].
Loncaric, Ante ;
Lamas, Juan Pablo ;
Guerra, Eugenia ;
Kopjar, Mirela ;
Lores, Marta .
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2018, 53 (05) :1195-1202
[33]   Development of an Energy Biorefinery Model for Chestnut (Castanea sativa Mill.) Shells [J].
Morana, Alessandra ;
Squillaci, Giuseppe ;
Paixao, Susana M. ;
Alves, Luis ;
La Cara, Francesco ;
Moura, Patricia .
ENERGIES, 2017, 10 (10)
[34]   Natural antioxidants from residual sources [J].
Moure, A ;
Cruz, JM ;
Franco, D ;
Domínguez, JM ;
Sineiro, J ;
Domínguez, H ;
Núñez, MJ ;
Parajó, JC .
FOOD CHEMISTRY, 2001, 72 (02) :145-171
[35]   The Potential Synergistic Modulation of AMPK by Lippia citriodora Compounds as a Target in Metabolic Disorders [J].
Olivares-Vicente, Marilo ;
Sanchez-Marzo, Noelia ;
Antonio Encinar, Jose ;
de la Luz Cadiz-Gurrea, Maria ;
Lozano-Sanchez, Jesus ;
Segura-Carretero, Antonio ;
Arraez-Roman, David ;
Riva, Catherine ;
Barrajon-Catalan, Enrique ;
Herranz-Lopez, Maria ;
Micol, Vicente .
NUTRIENTS, 2019, 11 (12)
[36]   ESTIMATION OF DIFFERENT PHENOLIC GROUPS IN VEGETABLE EXTRACTS [J].
PERI, C ;
POMPEI, C .
PHYTOCHEMISTRY, 1971, 10 (09) :2187-&
[37]   From soil to cosmetic industry: Validation of a new cosmetic ingredient extracted from chestnut shells [J].
Pinto, Diana ;
Cadiz-Gurrea, Maria De la Luz ;
Garcia, Juliana ;
Saavedra, Maria Jose ;
Freitas, Vitor ;
Costa, Paulo ;
Sarmento, Bruno ;
Delerue-Matos, Cristina ;
Rodrigues, Francisca .
SUSTAINABLE MATERIALS AND TECHNOLOGIES, 2021, 29
[38]   Castanea sativa shells: A review on phytochemical composition, bioactivity and waste management approaches for industrial valorization [J].
Pinto, Diana ;
Cadiz-Gurrea, Maria de la Luz ;
Vallverdu-Queralt, Anna ;
Delerue-Matos, Cristina ;
Rodrigues, Francisca .
FOOD RESEARCH INTERNATIONAL, 2021, 144
[39]   Optimizing the extraction of phenolic antioxidants from chestnut shells by subcritical water extraction using response surface methodology [J].
Pinto, Diana ;
Vieira, Elsa F. ;
Peixoto, Andreia F. ;
Freire, Cristina ;
Freitas, Vitor ;
Costa, Paulo ;
Delerue-Matos, Cristina ;
Rodrigues, Francisca .
FOOD CHEMISTRY, 2021, 334
[40]   Valorisation of underexploited Castanea sativa shells bioactive compounds recovered by supercritical fluid extraction with CO2: A response surface methodology approach [J].
Pinto, Diana ;
de la Luz Cadiz-Gurrea, Maria ;
Sut, Stefania ;
Ferreira, Ana Sofia ;
Leyva-Jimenez, Francisco Javier ;
Dall'Acqua, Stefano ;
Segura-Carretero, Antonio ;
Delerue-Matos, Cristina ;
Rodrigues, Francisca .
JOURNAL OF CO2 UTILIZATION, 2020, 40
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