[1] Kagawa Univ, Dept Pharmacol, Kita Ku, Kagawa 7610793, Japan
[2] Kagawa Univ, Life Sci Res Ctr, Kagawa 7610793, Japan
[3] Kagawa Univ, Dept Cardiorenal & Cerebrovasc Med, Kagawa 7610793, Japan
[4] Keio Univ, Sch Med, Dept Antiaging Med & Endocrinol, Tokyo, Japan
[5] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan