Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight

被引：17

作者：

Cinelli, Giulia ^{[1
]}

Fabrizi, Marta ^{[1
]}

Rava, Lucilla ^{[2
]}

Signore, Fabrizio ^{[3
]}

Vernocchi, Pamela ^{[4
]}

Semeraro, Michela ^{[1
]}

Vallone, Cristina ^{[3
]}

Lanciotti, Rosalba ^{[5
,6
]}

Degli Atti, Marta Ciofi ^{[2
]}

Manco, Melania ^{[1
]}

机构：

[1] IRCCS, Bambino Gesu Children Hosp, Res Unit Multifactorial Dis & Complex Phenotypes, Viale San Paolo 15, I-00146 Rome, Italy

[2] IRCCS, Bambino Gesu Childrens Hosp, Clin Epidemiol, Pzza S Onofrio 4, I-00165 Rome, Italy

[3] Usl Toscana Sud Est, Misericordia Hosp Grosseto, Dept Obstet & Gynaecol, I-58036 Grosseto, Italy

[4] IRCCS, Bambino Gesu Children Hosp, Unit Human Microbiome Genet & Rare Dis Area, Viale San Paolo 15, I-00146 Rome, Italy

[5] Univ Bologna Cesena, Ctr Interdipartimentale Ric Ind Agroalimentare, I-47521 Cesena, Italy

[6] Univ Bologna, Dipartimento Sci & Tecnol Agroalimentari, I-47521 Cesena, Italy

来源：

NUTRIENTS | 2018年 / 10卷 / 04期

关键词：

birth weight; small for gestational age; fatty acids; saturated fatty acids; FOR-GESTATIONAL-AGE; NEWBORN-INFANTS; GROWTH; TRANS; DIET; EXPRESSION; PREGNANCY; OBESITY; NUTRITION; DISEASE;

D O I：

10.3390/nu10040402

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Regular foetal development is crucial for assuring good health status in the offspring. The quality and quantity of maternal dietary fatty acids (FAs) can affect growth. The study aimed to: (1) investigate the association of maternal/foetal lipid profiles with birth weight (BW); and (2) compare these profiles in small, appropriate, and large for gestational age (SGA, AGA, and LGA) infants. FAs were measured in erythrocyte membranes using gas chromatography analysis in 607 mother-infant pairs (316 males, 52.1%). In the quantile regression, a significant association between BW and levels of maternal linoleic acid (LA; C18:2, n-6; coefficient: 18.66; p = 0.010), arachidonic acid (AA; C20:4, n-6; coefficient: 11.35; p = 0.007), docosahexaenoic acid (DHA; C22:6, n-3; coefficient: 29.73; p = 0.007), polyunsaturated FAs (coefficient: 8.55; p = 0.001), foetal DHA (coefficient: -22.82; p = 0.037), and saturated FAs (coefficient: -65.41; p = 0.002) was found. Myristic (C14:0) and pentadecanoic acids (C15:0), both maternal (p = 0.000; p = 0.017) and foetal (p = 0.009; p = 0.002), and maternal erucic acid (C22:1, n-9; p = 0.026) were found at higher levels in SGA infants as compared to AGA ones. Conversely, maternal LA, AA, and omega 6 FAs levels were higher in AGA infants (p = 0.037; p = 0.003; p = 0.026, respectively). Maternal and foetal polyunsaturated and omega 6 FAs levels are positively related to BW, while a lipid profile rich in saturated FAs and erucic acid may influence the risk of SGA.

引用

页数：12

共 32 条

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