Stereoselective total synthesis of polyketide lactone, (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone

被引：10

作者：

Sabitha, Gowravaram ^{[1
]}

Gopal, Peddabuddi ^{[1
]}

Yadav, Jhillu S. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 13期

关键词：

ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; REDUCTION;

D O I：

10.1016/j.tetasy.2009.06.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The total synthesis of lactone I has been described. The convergent asymmetric synthesis relies on the use of an Evans' syn-aldol, chain extension with lithio tert-butyl acetate, and the stereoselective reduction of a ketone as the key reactions. (C) 2009 Published by Elsevier Ltd.

引用

页码：1493 / 1499

页数：7

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