An efficient one-pot synthesis of bis(α-aminoalkyl)phosphinic acids, phosphorus-isosteric analogues of HIV protease inhibitors

被引：2

作者：

Vinyukov, Alexey V. ^{[1
]}

Borodachev, Alexey V. ^{[1
]}

Starikov, Andrey S. ^{[1
]}

Afanasyev, Alexey V. ^{[1
]}

Dmitriev, Maxim E. ^{[1
]}

Lednev, Boris V. ^{[1
]}

Ragulin, Valery V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Moscow Region, Russia

来源：

MENDELEEV COMMUNICATIONS | 2018年 / 28卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

IMMUNODEFICIENCY VIRUS-1 PROTEASE;

D O I：

10.1016/j.mencom.2018.05.022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An acid-catalyzed three-component reaction between hypo phosphorous acid, aldehydes and alkyl carbamates under mild conditions afforded bis(alpha-aminoalkyl)phosphinic acids. The proposed facile single-stage protocol is prospective for expansion of a range of phosphinic analogues of HIV protease inhibitors.

引用

页码：295 / 296

页数：2

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