Synthesis, Spectral Characterization and Biological Evaluation of Organotin(IV) Complexes of Aniline Derivatives of Naturally Occurring Betulinic Acid

Betulinic acid (tritcrpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (H-1 and C-13) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound (L2SnMe2)-Sn-2 was found with maximum antibacterial activity among the screened compounds. Compounds (L2SnMe2)-Sn-1 and (L2SnPh2)-Sn-1 were found with remarkable antifungal activity. Similarly L-1,(L2SnBu2)-Sn-1, L-2 and (L2SnMe3)-Sn-2 welt remarked with good antioxidant activity.