Breast microcalcifications studied with 3D contrast-enhanced high-field magnetic resonance imaging: More accuracy in the diagnosis of breast cancer

被引:12
|
作者
Trecate, G
Tess, JDT
Vergnaghi, D
Bergonzi, S
De Simone, T
Mariani, G
Musumeci, R
机构
[1] Natl Canc Res, Unit Diagnost Radiol A, Milan, Italy
[2] Natl Canc Res, Unit Diagnost Radiol C, Milan, Italy
[3] Natl Canc Res, Unit Med Oncol A, Milan, Italy
关键词
breast neoplasms; contrast enhancement; diagnosis; magnetic resonance; microcalcifications; time-intensity dynamic profiles;
D O I
10.1177/030089160208800308
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims: To evaluate the reliability of magnetic resonance imaging (MRI) performed with three-dimensional (3D) sequences in mammographically detected breast microcalcifications. Methods: During an 8-month period, a group of 28 patients with mammographically detected microcalcifications suspicious for malignancy underwent MRI. Their ages ranged from 33 to 65 years. Examinations were performed with a 1.5 Tesla MR unit and a 3D T1 weighted sequence. Images were interpreted on the basis of morphologic parameters and dynamic behavior in the uptake of contrast medium (Gd-DTPA). Histologic findings were considered as the gold reference. Results: Histologic analysis revealed invasive carcinoma in 7 patients, 3 of which were associated with foci of lobular car-cinoma in situ. Intraductal carcinoma was diagnosed in 8 patients, 1 of which was associated with a tubular carcinoma. Benign lesions accounted for 13 patients. All the neoplastic conditions showed enhancement on MR images (sensitivity, 100%), whereas early and intense enhancement was noted in 5 of 13 benign lesions (specificity, 61%). The positive predictive value was 75% and negative predictive value, 100%. Conclusions: Although an overlap in the enhancement behavior of malignant and some benign lesions is clearly evident, a careful interpretation of MR images is helpful in detecting and mainly ruling out breast cancer combined with mammographically suspicious microcalcifications.
引用
收藏
页码:224 / 233
页数:10
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