Bioactive Glass Fiber-Reinforced PGS Matrix Composites for Cartilage Regeneration

被引：34

作者：

Souza, Marina Trevelin ^{[1
]}

Tansaz, Samira ^{[2
]}

Zanotto, Edgar Dutra ^{[1
]}

Boccaccini, Aldo R. ^{[2
]}

机构：

[1] Univ Fed Sao Carlos UFSCar, Dept Mat Engn, Vitreous Mat Lab, CeRTEV Ctr Res Technol & Educ Vitreous Mat, BR-13565905 Sao Carlos, SP, Brazil

[2] Univ Erlangen Nurnberg, Inst Biomat, D-91058 Erlangen, Germany

来源：

MATERIALS | 2017年 / 10卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

poly(glycerol sebacate); bioactive glass; fibers; composite; cartilage; tissue engineering; POLY(GLYCEROL SEBACATE) SCAFFOLDS; TYMPANIC MEMBRANE PERFORATIONS; BIODEGRADABLE ELASTOMER; TISSUE; BONE; DEGRADATION; BEHAVIOR; REPAIR; NERVE; CELLS;

D O I：

10.3390/ma10010083

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Poly(glycerol sebacate) (PGS) is an elastomeric polymer which is attracting increasing interest for biomedical applications, including cartilage regeneration. However, its limited mechanical properties and possible negative effects of its degradation byproducts restrict PGS for in vivo application. In this study, a novel PGS-bioactive glass fiber (F18)-reinforced composite was developed and characterized. PGS-based reinforced scaffolds were fabricated via salt leaching and characterized regarding their mechanical properties, degradation, and bioactivity in contact with simulated body fluid. Results indicated that the incorporation of silicate-based bioactive glass fibers could double the composite tensile strength, tailor the polymer degradability, and improve the scaffold bioactivity.

引用

页数：14

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