Targeting gliomas with STAT3-silencing nanoparticles

被引：9
作者：
Kadiyala, Padma [1 ,2 ]
Gregory, Jason V. [3 ,4 ]
Lowenstein, Pedro R. [1 ,2 ,3 ]
Lahann, Joerg [3 ,4 ,5 ]
Castro, Maria G. [1 ,2 ,3 ]
机构：
[1] Univ Michigan, Sch Med, Dept Neurosurg, Ann Arbor, MI USA
[2] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI USA
[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Chem Engn, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Biomed Engn, Ann Arbor, MI 48109 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2021年 / 8卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Glioma; nanoparticles; systemic drug-delivery; targeted-therapy; immunotherapy; BRAIN;
D O I：
10.1080/23723556.2020.1870647
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood-brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat3 after systemic administration. Nanoparticles combined with radiation inhibited tumor progression and elicited anti-glioblastoma immunity in mice.
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页数：3
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